Name | 6 α-naloxol |
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Synonyms |
6a-Naloxol
6-Alpha Naloxol |
Description | 6-Alpha Naloxol(Alpha-Naloxol) is an opioid antagonist closely related to naloxone; a human metabolite of naloxone.IC50 value:Target: opioid antagonistWhen responding over the entire 30 min operant session was examined, naloxone was only 5-fold more potent than 6-alpha-naloxol in suppressing operant responding under Morphine Na ve conditions, but this increased to a 65-fold potency difference after Single or Repeat Morphine pretreatment. Examination of the relative potency of these antagonists in the Early Phase of operant testing (5-15 min post-antagonist) revealed an even greater 100-fold potency difference between naloxone and 6-alpha-naloxol, but in the Late Phase of testing (25-35 min post-antagonist), this had declined to a 9-fold potency difference, comparable to the relative potency of naloxone to 6-alpha-naloxol under Morphine-Na ve conditions. |
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Related Catalog | |
References |
[1]. Weinstein SH, et al. Metabolites of naloxone in human urine. J Pharm Sci. 1971 Oct;60(10):1567-8. |
Density | 1.43g/cm3 |
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Boiling Point | 532.5ºC at 760mmHg |
Molecular Formula | C19H23NO4 |
Molecular Weight | 329.39000 |
Flash Point | 275.8ºC |
Exact Mass | 329.16300 |
PSA | 73.16000 |
LogP | 1.03110 |
Vapour Pressure | 3.62E-12mmHg at 25°C |
Index of Refraction | 1.701 |
~93% 20410-95-1 |
Literature: MALLINCKRODT INC. Patent: WO2008/137672 A1, 2008 ; Location in patent: Page/Page column 25 ; |
~% 20410-95-1 |
Literature: Rezaie, Robert; Bailey, Timothy S. Patent: US2010/36128 A1, 2010 ; Location in patent: Page/Page column 7 ; |
~63% 20410-95-1 |
Literature: Hosztafi, Sandor; Berenyi, Sandor; Toth, Geza; Makleit, Sandor Monatshefte fuer Chemie, 1992 , vol. 123, # 5 p. 435 - 442 |
~% 20410-95-1 |
Literature: Hahn; Fishman Journal of Organic Chemistry, 1975 , vol. 40, # 1 p. 31 - 34 |
~% 20410-95-1 |
Literature: Hosztafi, Sandor; Berenyi, Sandor; Toth, Geza; Makleit, Sandor Monatshefte fuer Chemie, 1992 , vol. 123, # 5 p. 435 - 442 |
~% 20410-95-1 |
Literature: Hosztafi, Sandor; Berenyi, Sandor; Toth, Geza; Makleit, Sandor Monatshefte fuer Chemie, 1992 , vol. 123, # 5 p. 435 - 442 |
Precursor 5 | |
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DownStream 0 |