107489-37-2

107489-37-2 structure

Name: Thymoctonan
Chemical Name: (2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-1-[2-[[2-[[2-[[(2S)-2-amino-4-methylpentanoyl]amino]-4-carboxybutanoyl]amino]-3-carboxypropanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]hexanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
CAS Number: 107489-37-2
Molecular Formula: C₄₃H₆₇N₉O₁₃
Molecular Weight: 918.04500
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-09-21 20:36:54
Modify Date: 2024-01-17 18:28:22
Thymoctonan (THF-γ2) is the immunomodulatory octapeptide, thymic humoral factor γ2. Thymoctonan has the half-life less than 6 min at 37 °C in blood from human, rat and mouse[1].

Name	(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-1-[2-[[2-[[2-[[(2S)-2-amino-4-methylpentanoyl]amino]-4-carboxybutanoyl]amino]-3-carboxypropanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]hexanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
Synonyms	THF-gamma2 Thymoctonan Leu-Glu-Asp-Gly-Pro-Lys-Phe-Leu C43H67N9O13 thymic humoral factor gamma2

Description	Thymoctonan (THF-γ2) is the immunomodulatory octapeptide, thymic humoral factor γ2. Thymoctonan has the half-life less than 6 min at 37 °C in blood from human, rat and mouse[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	Thymoctonan 形成的主要片段在人和大鼠血液中为 Glu-Asp-Gly-Pro-Lys Phe-Leu (2-8)、Asp-Gly Pro-Lys-Phe-Leu (3-8) 和 Glu-Asp Gly-Pro-Rys (2-6)，在小鼠血液中为 2-8 和 2-6[1]。
References	[1]. Martignoni M, et al. Degradation of thymic humoral factor γ2 in human, rat and mouse blood: An experimental and theoretical study. Biochim Biophys Acta Proteins Proteom. 2020 Sep;1868(9):140467.