CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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DO7875000
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CAS REGISTRY NUMBER :
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67-04-9
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LAST UPDATED :
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199601
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DATA ITEMS CITED :
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7
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MOLECULAR FORMULA :
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C9-H13-N-O2.C4-H6-O6
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MOLECULAR WEIGHT :
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317.33
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WISWESSER LINE NOTATION :
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QR DYQ1M1 & 2 &QVYQYQVQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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4450 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 180,155,1969
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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2730 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 180,155,1969
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraduodenal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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3050 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 180,155,1969
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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2 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 237,171,1959
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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3200 mg/kg
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold
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REFERENCE :
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AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 166,437,1932 ** REPRODUCTIVE DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intramuscular
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DOSE :
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2087 mg/kg
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SEX/DURATION :
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female 7-16 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
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REFERENCE :
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AAMLAR Atti della Accademia Medica Lombarda. (c/o Prof. W. Montorsi, Festa del Perdono 3, Milan, Italy) V.20-29, 1931-40; New series: V.15- 1960- Volume(issue)/page/year: 25,203,1970
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intramuscular
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DOSE :
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1044 mg/kg
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SEX/DURATION :
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female 7-16 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - musculoskeletal system
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REFERENCE :
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AAMLAR Atti della Accademia Medica Lombarda. (c/o Prof. W. Montorsi, Festa del Perdono 3, Milan, Italy) V.20-29, 1931-40; New series: V.15- 1960- Volume(issue)/page/year: 25,203,1970
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