491871-58-0
491871-58-0 structure
- Name: TCS PIM-1 1
- Chemical Name: 6-(5-Bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydro-3-pyridine carbonitrile
- CAS Number: 491871-58-0
- Molecular Formula: C18H11BrN2O2
- Molecular Weight: 367.196
- Catalog: Signaling Pathways JAK/STAT Signaling Pim
- Create Date: 2016-03-02 23:40:30
- Modify Date: 2024-01-02 19:01:12
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TCS PIM-1 1(sc-204330) is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2(IC50s >20,000 nM).IC50 value: 50 nM [1]Target: Pim-1TCS PIM-1 1 bound convincingly within the ATP-binding site of Pim-1 suggesting an ATP-competitive inhibitory mechanism. Preliminary data further suggested that 1 lacked in vitro inhibitory activity toward related serine/threonine kinases Pim-2 and MEK1/2 (IC50 > 20 lM). Hence, small molecules similar to TCS PIM-1 1 may serve as useful starting scaffolds for the development of other improved yet selective Pim-1 inhibitors.
| Name | 6-(5-Bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydro-3-pyridine carbonitrile |
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| Synonyms |
2-oxo-4-phenyl-5H-furan-3-carbonitrile
6-(5-Bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile TCS PIM-1 1 3-cyano-4-phenyl-2(5H)-furanone 3-Cyano-4-phenyl-2(5H)-furanon 3-Cyan-4-phenyl-2(5H)-furanon 2-oxo-4-phenyl-2,5-dihydro-furan-3-carbonitrile 2-oxo-4-phenyl-2,5-dihydro-3-furancarbonitrile 3-Pyridinecarbonitrile, 6-(5-bromo-2-hydroxyphenyl)-1,2-dihydro-2-oxo-4-phenyl- 3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)-2-pyridone 3-cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone 6-(5-Bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydro-3-pyridinecarbonitrile |
| Description | TCS PIM-1 1(sc-204330) is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2(IC50s >20,000 nM).IC50 value: 50 nM [1]Target: Pim-1TCS PIM-1 1 bound convincingly within the ATP-binding site of Pim-1 suggesting an ATP-competitive inhibitory mechanism. Preliminary data further suggested that 1 lacked in vitro inhibitory activity toward related serine/threonine kinases Pim-2 and MEK1/2 (IC50 > 20 lM). Hence, small molecules similar to TCS PIM-1 1 may serve as useful starting scaffolds for the development of other improved yet selective Pim-1 inhibitors. |
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| Related Catalog | |
| References |
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 592.6±50.0 °C at 760 mmHg |
| Molecular Formula | C18H11BrN2O2 |
| Molecular Weight | 367.196 |
| Flash Point | 312.2±30.1 °C |
| Exact Mass | 366.000397 |
| PSA | 77.14000 |
| LogP | 4.60 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.728 |
| Storage condition | 2-8℃ |
