106372-55-8

106372-55-8 structure

Name: Aspartame acesulfame
Chemical Name: (5-Benzyl-3,6-dioxo-2-piperazinyl)acetic acid
CAS Number: 106372-55-8
Molecular Formula: C₁₃H₁₄N₂O₄
Molecular Weight: 262.26100
Catalog: Research Areas Neurological Disease
Create Date: 2017-01-31 17:36:07
Modify Date: 2024-01-06 16:12:09
Aspartame acesulfame is a methyl ester of a dipeptide. Aspartame acesulfame can be used as a synthetic nonnutritive sweetener. Aspartame acesulfame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%)[1][2].

Name	(5-Benzyl-3,6-dioxo-2-piperazinyl)acetic acid
Synonyms	Benzoacenaphthylene Acesulfame Aspartame Salt 4,5-Benzoacenaphthylene Benz(e)acenaphthylene acessulfame-aspartame

Description	Aspartame acesulfame is a methyl ester of a dipeptide. Aspartame acesulfame can be used as a synthetic nonnutritive sweetener. Aspartame acesulfame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%)[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Aspartame is composed of phenylalanine (an important role in neurotransmitter regulation), aspartic acid (an excitatory neurotransmitter in the central nervous system) and methanol[2].
In Vivo	Aspartame (4000 mg/kg bw/day; p.o.) shows no adverse effect in acute, subacute and chronic toxicity studies with aspartame, and its decomposition products, conducted in mice, rats, hamsters and dogs[1].
References	[1]. Magnuson BA, et, al. Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies. Crit Rev Toxicol. 2007;37(8):629-727. [2]. Humphries P, et, al. Direct and indirect cellular effects of aspartame on the brain. Eur J Clin Nutr. 2008 Apr;62(4):451-62.

RIDADR	UN 2811 6.1 / PGIII