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53066-26-5

53066-26-5 structure
53066-26-5 structure
  • Name: Lexithromycin
  • Chemical Name: (E)-9-deoxo-9-methoxyiminoerythromycin A
  • CAS Number: 53066-26-5
  • Molecular Formula: C38H70N2O13
  • Molecular Weight: 762.96800
  • Catalog: Signaling Pathways Anti-infection Bacterial
  • Create Date: 2016-03-26 22:12:37
  • Modify Date: 2024-01-10 17:33:40
  • Lexithromycin is an erythromycin A derivative, with antibacterial activity.

Name (E)-9-deoxo-9-methoxyiminoerythromycin A
Synonyms (E)-9-chloro-4-methyl-8-(tetrahydro-2H-pyran-2-yloxy)-4-nonenoic acid
4-Nonenoic acid,9-chloro-4-methyl-8-[(tetrahydro-2H-pyran-2-yl)oxy]
Description Lexithromycin is an erythromycin A derivative, with antibacterial activity.
Related Catalog
Target

Bacterial[1]

In Vitro Lexithromycin is an erythromycin A derivative, with antibacterial activity. Lexithromycin shows minimal inhibitory concentration (MIC) of 0.06 μg/mL against S. pyogenes CN10A and Streptococcus sp. 64/848C, 0.25 μg/mL against Staphylococcus aureus Oxford, 0.5 μg/mL against S. aureus Russell and S. aureus T2, 4 μg/mL against S. pyogenes CN10A and Haemophilus influenzae Wy 21[1].
References

[1]. Hunt E, et al. Erythromycin A 11,12-methylene acetal. J Antibiot (Tokyo). 1988 Nov;41(11):1644-8.

Density 1.26g/cm3
Boiling Point 824.6ºC at 760mmHg
Molecular Formula C38H70N2O13
Molecular Weight 762.96800
Flash Point 452.5ºC
Exact Mass 762.48800
PSA 198.43000
LogP 2.21890
Index of Refraction 1.543
Storage condition 2-8℃

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53066-26-5 structure

53066-26-5

Literature: Everett, Jeremy R.; Hatton, Ian K.; Hunt, Eric; Tyler, John W.; Williams, David J. Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1989 , p. 1719 - 1728