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Dayang Chem (Hangzhou) Co., Ltd.
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Product Name: Isoquinoline,1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-
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1699-51-0

1699-51-0 structure

1699-51-0 structure

Name: DL-LAUDANOSINE
Chemical Name: dl-laudanosine
CAS Number: 1699-51-0
Molecular Formula: C₂₁H₂₇NO₄
Molecular Weight: 357.44300
Catalog: Research Areas Neurological Disease
Create Date: 2018-07-25 16:20:31
Modify Date: 2024-01-07 08:46:36
DL-Laudanosine, an Atracurium and Cisatracurium metabolite, crosses the blood–brain barrier and may cause excitement and seizure activity[1].

Name	dl-laudanosine
Synonyms	(R)-Laudanosine LAUDANOSINE,DL-(SH) (+/-)-LAUDANOSIDE (+-)-laudanosine LAUDANOSINE,DL-(SH)(CALL) LAUDANOSINE,DL DL-LAUDANOSIDE

Description	DL-Laudanosine, an Atracurium and Cisatracurium metabolite, crosses the blood–brain barrier and may cause excitement and seizure activity[1].
Related Catalog	Research Areas >> Neurological Disease
In Vivo	DL-Laudanosine (Laudanosine) appears to be unique in its ability to produce cerebral stimulation in lightly anaesthetized animals and it is reported to cause arousal from anaesthesia in subconvulsive doses[1]. Animal Model: Male CFLP mice weighing 18-25 g, and male Wistar rats weighing 120-150 g [2]. Dosage: 10-20 mg/kg. Administration: IV. Result: Caused convulsions and hind limb extensions.
References	[1]. V Fodale, et al. Laudanosine, an Atracurium and Cisatracurium Metabolite. Eur J Anaesthesiol. 2002 Jul;19(7):466-73. [2]. D J Chapple, et al. Cardiovascular and Neurological Effects of Laudanosine. Studies in Mice and Rats, and in Conscious and Anaesthetized Dogs. Br J Anaesth. 1987 Feb;59(2):218-25.

Melting Point	115â„ƒ
Molecular Formula	C₂₁H₂₇NO₄
Molecular Weight	357.44300
Exact Mass	357.19400
PSA	40.16000
LogP	3.43060

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NX5070000

CHEMICAL NAME :: Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratryl- , (+-)-

CAS REGISTRY NUMBER :: 1699-51-0

LAST UPDATED :: 198209

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H27-N-O4

MOLECULAR WEIGHT :: 357.49

WISWESSER LINE NOTATION :: T66 CNT&J B1R CO1 DO1& C1 HO1 IO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 47 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 20,894,1977

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301 + H311 + H331
Precautionary Statements	Missing Phrase - N15.00950417-P261-P280-P302 + P352 + P312-P304 + P340 + P312-P403 + P233
Risk Phrases	26/28-40
Safety Phrases	22-24/25
RIDADR	UN 2810
HS Code	2933499090

Precursor 0
DownStream 9
475-81-0 494-99-5 120-14-9 7306-46-9
16620-96-5 20323-75-5 6514-05-2 2934-97-6
93-03-8

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%