Shanghai Nianxing Industrial Co., Ltd
China
Product Name: ISO-1
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: ISO-1
Price: $470.4/50mg $600.0/100mg $1000.0/250mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

ShangHai DC Chemicals Co.,Ltd
China
Product Name: ISO-1
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: METHYL 2-(3-(4-HYDROXYPHENYL)-4,5-DIHYDROISOXAZOL-5-YL)ACETATE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

478336-92-4

478336-92-4 structure

478336-92-4 structure

Name: ISO-1
Chemical Name: methyl 2-[3-(4-oxocyclohexa-2,5-dien-1-ylidene)-1,2-oxazolidin-5-yl]acetate
CAS Number: 478336-92-4
Molecular Formula: C₁₂H₁₃NO₄
Molecular Weight: 235.236
Catalog: Research Areas Inflammation/Immunology
Create Date: 2016-06-28 11:25:51
Modify Date: 2024-01-07 21:55:16
ISO-1 is a macrophage migration inhibitory factor (MIF) antagonist with an IC50 of 7 μM.

Name	methyl 2-[3-(4-oxocyclohexa-2,5-dien-1-ylidene)-1,2-oxazolidin-5-yl]acetate
Synonyms	Methyl [3-(4-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]acetate UNII-7QFF3Z0V9X MIF Antagonist,ISO-1 5-Isoxazoleacetic acid, 4,5-dihydro-3-(4-hydroxyphenyl)-, methyl ester 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER 3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazoleacetic acid methyl ester UNII:7QFF3Z0V9X Macrophage Migration Inhibitory Factor Antagonist,ISO-1 ISO-1

Description	ISO-1 is a macrophage migration inhibitory factor (MIF) antagonist with an IC50 of 7 μM.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Lubetsky JB, et al. The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. J Biol Chem. 2002 Jul 12;277(28):24976-82. [2]. Al-Abed Y, et al. ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis. J Biol Chem. 2005 Nov 4;280(44):36541-4. [3]. Nothnick WB, et al. Inhibition of macrophage migration inhibitory factor reduces endometriotic implant size in mice with experimentally induced disease. J Endometr. 2011 Sep 30;3(3):135-142.

Density	1.3±0.1 g/cm3
Boiling Point	365.0±48.0 °C at 760 mmHg
Melting Point	114 °C
Molecular Formula	C₁₂H₁₃NO₄
Molecular Weight	235.236
Flash Point	174.6±29.6 °C
Exact Mass	235.084457
PSA	64.63000
LogP	0.89
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.582

HS Code	2934999090

Precursor 4
1056465-52-1 109272-34-6 123-08-0 699-06-9
DownStream 0

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%