847949-51-3

847949-51-3 structure

Name: Gefitinib N-oxide
Chemical Name: N-(3-chloro-4-fluorophenyl)-[7-methoxy-6-(3-(4-(1-oxymorpholinyl))propoxy)-4-quinazolin]amine
CAS Number: 847949-51-3
Molecular Formula: C₂₂H₂₄ClFN₄O₄
Molecular Weight: 462.90200
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2018-09-15 04:39:29
Modify Date: 2024-02-13 18:29:00
Gefitinib N-oxide is the N-oxide derivative of Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells[1][2].

Name	N-(3-chloro-4-fluorophenyl)-[7-methoxy-6-(3-(4-(1-oxymorpholinyl))propoxy)-4-quinazolin]amine
Synonyms	Gefitinib Morpholine N-oxide Gefitinib N-Oxide gefitinib N-oxide Gefitinib Impurity 13

Description	Gefitinib N-oxide is the N-oxide derivative of Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	IC50: 37 nM (Tyr1173 site, in NR6wtEGFR cells), 37 nM (Tyr992 site, in NR6wtEGFR cells)[1]
References	[1]. Pedersen MW, et al. Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII. Br J Cancer. 2005 Oct 17;93(8):915-23. [2]. Moasser MM, et al. The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res. 2001 Oct 1;61(19):7184-8.