42607-87-4

42607-87-4 structure

Name: THP-PEG7
Chemical Name: 5,5-Dimethyl-4-methoxy-3-oxazolin-2-on
CAS Number: 42607-87-4
Molecular Formula: C₁₇H₃₄O₈
Molecular Weight: 232.23900
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2016-08-19 09:25:24
Modify Date: 2024-01-05 16:53:54
THP-PEG6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. THP-PEG6-OH is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

Name	5,5-Dimethyl-4-methoxy-3-oxazolin-2-on
Synonyms	4-methoxy-5,5-dimethyl-5H-oxazol-2-one 4-Methoxy-5,5-dimethyl-5H-oxazol-2-on

Description	THP-PEG6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. THP-PEG6-OH is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Non-cleavable
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [2]. Masahiro Tomita, et al. Antibody specifically recognizing resin plasticizer compound. WO2005105846A1.

Hazard Codes	Xi

Precursor 0
DownStream 2
3386-18-3 868594-48-3