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1953-04-4

1953-04-4 structure
1953-04-4 structure
  • Name: Galantamine hydrobromide
  • Chemical Name: Galanthamine hydrobromide
  • CAS Number: 1953-04-4
  • Molecular Formula: C17H22BrNO3
  • Molecular Weight: 368.266
  • Catalog: API Nervous system medication Cholinergic
  • Create Date: 2018-03-30 08:00:00
  • Modify Date: 2024-01-02 08:10:43
  • Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase(AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. IC50 Value: 410 nM Target: AChEGalanthamine hydrobromide prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.
Name Galanthamine hydrobromide
Synonyms (4aS,6R,8aS)-3-Methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-olhydrobromid
NIVALIN,HBR
MFCD00067672
(4aS,6R,8aS)-3-methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide
(4aS,6R,8aS)-3-méthoxy-11-méthyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazépin-6-ol bromhydrate
Galanthamine hydrobromide (1:1)
GALANTHAMIDE HYDROBROMIDE
[3H]-Galantamine hydrobromide
UNII:5N4SA4KQX9
galanthamine bromhydrate (1:1)
Galantamine hydrobromide (JAN/USAN)
Galanthamine HBr
Galanthamine (hydrobromide)
Galantamine hydrobromide
(-)-Galanthaminium bromide
NIVALIN
6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aS,6R,8aS)-, hydrobromide (1:1)
galanthaminhydrobromid(1:1)
GALANTHAMINE HYDROBROMIDUM
EINECS 217-780-5
GALANTAMINE HBR
6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aS,6R,8aS)-, hydrobromide
Description Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase(AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. IC50 Value: 410 nM Target: AChEGalanthamine hydrobromide prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.
Related Catalog
References

[1]. Kita Y, Ago Y, Takano E, Fukada A, Takuma K, Matsuda T.Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic acetylcholine receptors in mice.Psychopharmacology (Berl). 2012 Aug 30.

[2]. Berkov S, Viladomat F, Codina C, Suárez S, Ravelo A, Bastida J.GC-MS of amaryllidaceous galanthamine-type alkaloids.J Mass Spectrom. 2012 Aug;47(8):1065-73.

[3]. Park CW, Son DD, Kim JY, Oh TO, Ha JM, Rhee YS, Park ES.Investigation of formulation factors affecting in vitro and in vivo characteristics of a galantamine transdermal system.Int J Pharm. 2012 Oct 15;436(1-2):32-40. Epub 2012 Jul 5.

[4]. Park YS, Kim SH, Kim SY, Kim YH, Lee MH, Yang SC, Shaw LM, Kang JS.Quantification of Galantamine in Human Plasma by Validated Liquid Chromatography-Tandem Mass Spectrometry using Glimepride as an Internal Standard: Application to Bioavailability Studies in 32 Healthy Korean Subjects.J Chromatogr Sci. 2012 Jun 28.

[5]. Arias et al Galantamine prevents apoptosis induced by b-amyloid and thapsigargin: involvement of nicotinic acetycholine receptors. Neuropharmacology (2004) 46 103.
Melting Point 256 °C
Molecular Formula C17H22BrNO3
Molecular Weight 368.266
Exact Mass 367.078308
PSA 41.93000
LogP 2.74630
Vapour Pressure 0mmHg at 25°C
Index of Refraction -95 ° (C=1.4, H2O)
Storage condition −20°C
Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements P301 + P310
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T
Risk Phrases R25:Toxic if swallowed.
Safety Phrases 45-36/37/39-22
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS DF8075000

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title: CAS No. 1953-04-4 | Chemsrc address: https://www.chemsrc.com/en/baike/509834.html

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