224445-12-9

224445-12-9 structure

Name: BIS(7)-TACRINE
Chemical Name: N,N'-bis(1,2,3,4-tetrahydroacridin-9-yl)heptane-1,7-diamine,dihydrochloride
CAS Number: 224445-12-9
Molecular Formula: C₃₃H₄₂Cl₂N₄
Molecular Weight: 565.619
Create Date: 2016-03-03 16:13:19
Modify Date: 2024-01-10 18:35:25
Bis(7)-tacrine dihydrochloride is a dimeric AChE inhibitor derived from tacrine. Bis(7)-tacrine dihydrochloride prevents glutamate-induced neuronal apoptosis by blocking NMDA receptors. Bis(7)-tacrine dihydrochloride is a potent GABAAreceptor antagonist. Bis(7)-tacrine dihydrochloride has the potential for the research of Alzheimer's disease [1][2][3].

Name	N,N'-bis(1,2,3,4-tetrahydroacridin-9-yl)heptane-1,7-diamine,dihydrochloride
Synonyms	N,N'-Di(1,2,3,4-tetrahydro-9-acridinyl)-1,7-heptanediamine dihydrochloride 9-Amino-1,2,3,4-tetrahydroacridine bis 1,7-heptylene dihydrochloride Tacrine-Based Inhibitor 2f heptylene-bis(tacrine) dihydrochloride heptylene-bis(THA) dihydrochloride 1,7-Heptanediamine, N,N-bis(1,2,3,4-tetrahydro-9-acridinyl)-, hydrochloride (1:2)

Description	Bis(7)-tacrine dihydrochloride is a dimeric AChE inhibitor derived from tacrine. Bis(7)-tacrine dihydrochloride prevents glutamate-induced neuronal apoptosis by blocking NMDA receptors. Bis(7)-tacrine dihydrochloride is a potent GABAAreceptor antagonist. Bis(7)-tacrine dihydrochloride has the potential for the research of Alzheimer's disease [1][2][3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> AChE
References	[1]. Li XY, et al. Actions of bis(7)-tacrine and tacrine on transient potassium current in rat DRG neurons and potassium current mediated by K(V)4.2 expressed in Xenopus oocyte. Brain Res. 2010;1318:23-32. [2]. Li CY, et al. Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABA(A) receptor antagonist. Neuroreport. 1999;10(4):795-800. [3]. Luo J, et al. Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currents. Biochem Biophys Res Commun. 2007;361(2):505-509.