3858-89-7

3858-89-7 structure

Name: Chloroprocaine Hydrochloride
Chemical Name: chloroprocaine hydrochloride
CAS Number: 3858-89-7
Molecular Formula: C₁₃H₂₀Cl₂N₂O₂
Molecular Weight: 307.216
Catalog: API Anesthetic Agents Local anesthetics
Create Date: 2018-05-10 08:00:00
Modify Date: 2024-01-02 09:11:35
Chloroprocaine hydrochloride (2-Chloroprocaine hydrochloride) is a potent inhibitor of Na,K-ATPase activity with an IC50 of 13 mM. Chloroprocaine hydrochloride blocks peripheral nerve[1].

Name	chloroprocaine hydrochloride
Synonyms	NESACAINE-MPF 4-amino-2-chlorobenzoate de 2-(diéthylamino)éthyle chlorhydrate 2-diethylaminoethyl 4-amino-2-chlorobenzoate hydrochloride Benzoic acid, 4-amino-2-chloro-, 2-(diethylamino)ethyl ester, hydrochloride (1:1) 2-(Diethylamino)ethyl 4-amino-2-chlorobenzoate hydrochloride (1:1) 2-(Diethylamino)ethyl-4-amino-2-chlorbenzolcarboxylathydrochlorid 2-Chloro-4-aminobenzoic Acid Diethylaminoethyl Ester Hydrochloride 4-Amino-2-chlorobenzoic Acid 2-(Diethylamino)ethyl Ester Monohydrochloride CHLOROPROCAINE HCL Chloroprocaine Hydrochloride 2-(diethylamino)ethyl 4-amino-2-chlorobenzoate,hydrochloride UNII-LT7Z1YW11H Nesacaine Chlorprocainchlorid

Description	Chloroprocaine hydrochloride (2-Chloroprocaine hydrochloride) is a potent inhibitor of Na,K-ATPase activity with an IC50 of 13 mM. Chloroprocaine hydrochloride blocks peripheral nerve[1].
Related Catalog	Research Areas >> Neurological Disease
Target	IC50: 13 mM (Na,K-ATPase)[1]
In Vivo	In mice, the intravenous LD50 of Chloroprocaine hydrochloride is 97 mg/kg and the subcutaneous LD50 of Chloroprocaine hydrochloride is 950 mg/kg[1].
References	[1]. H Kutchai, et al. Inhibition of the Na,K-ATPase of Canine Renal Medulla by Several Local Anesthetics. Pharmacol Res. 2001 Apr;43(4):399-403. [2]. Chloroprocaine HCl Injection.

Boiling Point	402.6ºC at 760 mmHg
Melting Point	176ºC
Molecular Formula	C₁₃H₂₀Cl₂N₂O₂
Molecular Weight	307.216
Exact Mass	306.090179
PSA	41.57000
LogP	3.62590
Storage condition	-20℃
Stability	Stable. Incompatible with strong oxidizing agents.

CHEMICAL NAME :: Benzoic acid, 4-amino-2-chloro-, 2-(diethylamino)ethyl ester, hydrochloride

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - coma Vascular - BP lowering not characterized in autonomic section

REFERENCE :: AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957- Volume(issue)/page/year: 66,677,1987

TOXIC EFFECTS :: Peripheral Nerve and Sensation - local anesthetic Behavioral - convulsions or effect on seizure threshold

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 54,501,1980

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 75,215,1955

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 3,525,1961 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5336 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 166 (estimated) No. of Female Employees: 105 (estimated)

RIDADR	NONH for all modes of transport

Precursor 2
2457-76-3 14426-20-1
DownStream 0