3858-89-7

• 常用中文名：盐酸氯普鲁卡因
• 常用英文名：Chloroprocaine Hydrochloride
• CAS号：3858-89-7
• 分子式：C₁₃H₂₀Cl₂N₂O₂
• 分子量：307.216
• 相关类别： 原料药 Anesthetic Agents Local anesthetics
• 发布时间：2018-05-10 08:00:00
• 更新时间：2024-01-02 09:11:35
• Chloroprocaine hydrochloride (2-Chloroprocaine hydrochloride) 是一种酯类麻醉剂。Chloroprocaine 是一种有效的 Na,K-ATPase 活性抑制剂,IC50 为 13 mM。Chloroprocaine hydrochloride 阻断外周神经。

名称

• 中文名: 盐酸氯普鲁卡因
• 英文名: chloroprocaine hydrochloride
• 中文别名: 4-氨基-2-氯苯甲酸 2-(二乙氨基)乙酯盐酸盐; 纳塞卡因
• 英文别名: NESACAINE-MPF; 4-amino-2-chlorobenzoate de 2-(diéthylamino)éthyle chlorhydrate; 2-diethylaminoethyl 4-amino-2-chlorobenzoate hydrochloride; Benzoic acid, 4-amino-2-chloro-, 2-(diethylamino)ethyl ester, hydrochloride (1:1); 2-(Diethylamino)ethyl 4-amino-2-chlorobenzoate hydrochloride (1:1); 2-(Diethylamino)ethyl-4-amino-2-chlorbenzolcarboxylathydrochlorid; 2-Chloro-4-aminobenzoic Acid Diethylaminoethyl Ester Hydrochloride; 4-Amino-2-chlorobenzoic Acid 2-(Diethylamino)ethyl Ester Monohydrochloride; CHLOROPROCAINE HCL; Chloroprocaine Hydrochloride; 2-(diethylamino)ethyl 4-amino-2-chlorobenzoate,hydrochloride; UNII-LT7Z1YW11H; Nesacaine; Chlorprocainchlorid

物化性质

• 沸点: 402.6ºC at 760 mmHg
• 熔点: 176ºC
• 分子式: C₁₃H₂₀Cl₂N₂O₂
• 分子量: 307.216
• 精确质量: 306.090179
• PSA: 41.57000
• LogP: 3.62590
• 外观性状: 白色结晶粉末
• 储存条件: -20℃
• 稳定性: Stable. Incompatible with strong oxidizing agents.

生物活性

• 描述: Chloroprocaine hydrochloride (2-Chloroprocaine hydrochloride) 是一种酯类麻醉剂。Chloroprocaine 是一种有效的 Na,K-ATPase 活性抑制剂,IC50 为 13 mM。Chloroprocaine hydrochloride 阻断外周神经。
• 相关类别:
  研究领域 >> 神经疾病
• 靶点:

  IC50: 13 mM (Na,K-ATPase)[1]

• 体内研究: 小鼠静脉注射盐酸氯普鲁卡因的LD50为97mg/kg,皮下注射盐酸氯普鲁卡因的LD50为950mg/kg[1]。
• 参考文献:

  [1]. H Kutchai, et al. Inhibition of the Na,K-ATPase of Canine Renal Medulla by Several Local Anesthetics. Pharmacol Res. 2001 Apr;43(4):399-403.

  [2]. Chloroprocaine HCl Injection.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DG1575200 CHEMICAL NAME : Benzoic acid, 4-amino-2-chloro-, 2-(diethylamino)ethyl ester, hydrochloride CAS REGISTRY NUMBER : 3858-89-7 LAST UPDATED : 199504 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C13-H19-Cl-N2-O2.Cl-H MOLECULAR WEIGHT : 307.25 WISWESSER LINE NOTATION : ZR CG DVO2N2&2 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraspinal SPECIES OBSERVED : Human - woman DOSE/DURATION : 9677 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - coma Vascular - BP lowering not characterized in autonomic section REFERENCE : AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957- Volume(issue)/page/year: 66,677,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 266 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - local anesthetic Behavioral - convulsions or effect on seizure threshold REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 54,501,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 700 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 75,215,1955 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 65 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 3,525,1961 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5336 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 166 (estimated) No. of Female Employees: 105 (estimated)

安全

• 危险品运输编码: NONH for all modes of transport

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