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6358-69-6

6358-69-6 structure
6358-69-6 structure
Name pyranine
Synonyms Trisodium 8-hydroxy-1,3,6-pyrenetrisulfonate
Solvent Green 7
trisodium,8-hydroxypyrene-1,3,6-trisulfonate
EINECS 228-783-6
1,3,6-Pyrenetrisulfonic acid, 8-hydroxy-, sodium salt (1:3)
MFCD00037575
trisodium 8-hydroxypyrene-1,3,6-trisulfonate
Description Pyranine as a new class of fluorescent chemosensor for the Cu+ ion is reported.
Related Catalog
In Vitro Pyranine is capable of discriminating ranges of cations from the Cu+ ion, even in competing environment. Pyranine displays a rapid fluorescence response (t1/2=1.66 min) towards the Cu+ ion, and the micromolar detection limit enables the detection of the ion in environmental samples. The observed stoichiometry of complexation between Pyranine and Cu+ is 2:1[1]. The pH-sensitive fluorescent indicator Pyranine is studied to determine its usefulness as probes for the living cornea and anterior chamber. Pyranine has properties which render it almost ideally suited for this purpose. Adequate concentrations are reached in the cornea and anterior chamber after topical administration; measurements can be made by fluorophotometry for many hours. The pH is calculated by measuring the ratio of fluorescent intensity at two excitation wavelengths, I463/I404, a measurement which is dependent on pH but independent of the concentration of the fluorophore and other variables which can alter the intensity. In the rabbit eye, Pyranine in the cornea and anterior chamber is observed to undergo easily measurable changes in fluorescent ratios associated with lid closure and contact lens wear, indicating its sensitivity to mild changes in pH[2]. Pyranine (Py) is a fluorescence probe[3].
Cell Assay PAAm-κC composite gels are prepared by free-radical copolymerization using 0.71 g of AAm, 0.01 g of BIS (N, N’-methylenebisacrylamide), 0.008 g of APS (ammonium persulfate) and 2 µl of TEMED (tetramethylethylenediamine) are dissolved in 5 mL of distilled water (pH 6.5) by heating. The heated mixture solution is held at 80°C. Then different amounts of κ-carrageenan (0.5, 1, 1.5, 2, 2.5 and 3 (w/v) % κC) are added. Pyranine (Py) is used in the PAAm–κC composites as a fluorescence probe, which is a derivative of pyrene possessing three SO3- groups, which can form bonds with positive charges on the gel. Pyranine (Py) concentration is kept constant at 4×10-4 M, for all experiments. The solution is stirred (200 rpm) for 15 min to achieve a homogenous sample solution. All samples are deoxygenated by bubbling nitrogen for 10 min just before the polymerization process. The drying and swelling experiments of disc-shaped PAAm–κC composite gels prepared are performed in air and in water, respectively, at various temperatures (30, 40, 50, and 60°C). A model LS-50 spectrometer equipped with a temperature controller is used for fluorescence intensity measurements, which are made at a 90° position and spectral bandwidths are kept at 5 nm. Disc-shaped gel samples are placed on the wall of a 1-cm path-length square quartz cell filled with air and/or water for the drying and swelling experiments[3].
References

[1]. Saha T, et al. In vitro sensing of Cu(+) through a green fluorescence rise of pyranine. Photochem Photobiol Sci. 2014 Oct;13(10):1427-33.

[2]. Thomas JV, et al. The fluorescent indicator pyranine is suitable for measuring stromal and cameral pH in vivo. Exp Eye Res. 1990 Mar;50(3):241-9.

[3]. Evingür GA, et al. Kinetic models for the dynamical behavior of polyacrylamide (PAAm)-κ-carrageenan (κC) composite gels. J Biol Phys. 2015 Jan;41(1):37-47.
Density 2.15
Boiling Point 171-178 °C10 mm Hg(lit.)
Melting Point 62-63.5 °C(lit.)
Molecular Formula C16H7Na3O10S3
Molecular Weight 524.385
Flash Point 250 °C
Exact Mass 523.889465
PSA 216.97000
LogP 4.24430
Water Solubility 300 g/L (25 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UR2700000
CHEMICAL NAME :
1,3,6-Pyrenetrisulfonic acid, 8-hydroxy-, trisodium salt
CAS REGISTRY NUMBER :
6358-69-6
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C16-H7-O10-S3.3Na
MOLECULAR WEIGHT :
524.38
WISWESSER LINE NOTATION :
L666 B6 2AB PJ DSWO HSWO KQ OSWO &-NA- 3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1050 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 44,225,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X8711 No. of Facilities: 2864 (estimated) No. of Industries: 12 No. of Occupations: 39 No. of Employees: 226640 (estimated) No. of Female Employees: 180101 (estimated)
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S36/37-S37/39-S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS UR2700000
HS Code 3204170000
Precursor  0

DownStream  1

HS Code 2906299090
Summary 2906299090 other aromatic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

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