25913-34-2
25913-34-2 structure
- Name: Tinoridine hydrochloride
- Chemical Name: ethyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate monohydrochloride
- CAS Number: 25913-34-2
- Molecular Formula: C17H21ClN2O2S
- Molecular Weight: 352.87900
- Catalog: API Antipyretic analgesics Non-steroidal anti-inflammatory drugs
- Create Date: 2018-07-15 16:42:52
- Modify Date: 2024-01-11 16:01:45
-
Tinoridine hydrochloride is a nonsteroidal anti-inflammatory drug and also has potent radical scavenger and antiperoxidative activity.
| Name | ethyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate monohydrochloride |
|---|---|
| Synonyms |
Tinoridine Hydrochloride
Dimaten Thieno(2,3-C)pyridine-3-carboxylic acid,4,5,6,7-tetrahydro-2-amino-6-benzyl-,ethyl ester,monohydrochloride Tinoridine HCl 2-Amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine hydrochloride Tenocyclidine hydrochloride 2-Amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno(2,3-C)pyridine monohydrochloride Nonflamin Einecs 247-342-9 |
| Description | Tinoridine hydrochloride is a nonsteroidal anti-inflammatory drug and also has potent radical scavenger and antiperoxidative activity. |
|---|---|
| Related Catalog | |
| In Vitro | Tinoridine reduces a stable free radical, diphenyl-p-picrylhydrazyl, in the molar ratio of about 1:2, indicating its free radical scavenging ability. Tinoridine inhibits the lipid peroxidation in rat liver microsomes induced by xanthine-xanthine oxidase system in the presence of ADP and Fe2+, in which hydroxyl radical is formed. Tinoridine is demonstrated to be oxidized in the course of the lipid peroxidation by following the fluorescence derived from the oxidation product of tinoridine. It is also oxidized by the xanthine-xanthine oxidase system in the presence of Fe2+, but its oxidation is slow in the absence of Fe2+ and almost completely inhibited by catalase. Tinoridine is also oxidized by H2O2-Fe2+ system producing OH (Fenton reaction), but it does not affect the reduction of cytochrome c caused by superoxide radical[1]. |
| In Vivo | CCl4 aministration produces a marked decrease in the concentrations of liver microsomal cytochrome P-450 and G6Pase, indicating that hepatic endoplasmic reticulum function is disrupted. Prior treatment of the animals with tinoridine (100 mg/kg) significantly reduces the CCl4-induced alterations in the enzyme activities, and a rapid recovery toward the normal values is observed[2]. |
| Kinase Assay | CCl4 aministration produces a marked decrease in the concentrations of liver microsomal cytochrome P-450 and G6Pase, indicating that hepatic endoplasmic reticulum function is disrupted. Prior treatment of the animals with tinoridine (100 mg/kg) significantly reduces the CCl4-induced alterations in the enzyme activities, and a rapid recovery toward the normal values is observed[2]. |
| Animal Admin | Rat: Male Wistar rats (180-220 g) are used in the experiments. Drugs (Tinoridine) are given orally as a suspension in 0.5% methylcellulose solution 1 hr before CCl4, administration. Control animals receive an equivalent amount of the vehicle. CCl4 is administered ip at a dose of 0.25 ml/kg as a 5% (v/v) solution in olive oil. The animals are killed by carotid excision at different times after CCl4 administration; the livers are rapidly removed, weighed and processed for biochemical or histologic analysis[2]. |
| References |
| Density | 1.256g/cm3 |
|---|---|
| Boiling Point | 493.5ºC at 760mmHg |
| Melting Point | 234-235° (dec) |
| Molecular Formula | C17H21ClN2O2S |
| Molecular Weight | 352.87900 |
| Flash Point | 252.3ºC |
| Exact Mass | 352.10100 |
| PSA | 83.80000 |
| LogP | 4.38640 |
| Vapour Pressure | 7E-10mmHg at 25°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|