Dayang Chem (Hangzhou) Co., Ltd.
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Product Name: Ipenoxazone
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104454-71-9

104454-71-9 structure

104454-71-9 structure

Name: Ipenoxazone
Chemical Name: Ipenoxazone
CAS Number: 104454-71-9
Molecular Formula: C₂₂H₃₄N₂O₂
Molecular Weight: 358.51800
Catalog: Research Areas Neurological Disease
Create Date: 2018-06-13 18:33:18
Modify Date: 2024-01-08 15:23:42
Ipenoxazone is a potent and centrally acting muscle relaxant.

Name	Ipenoxazone
Synonyms	Ipenoglan NC-1200 (4S,5R)-3-[3-(Hexahydro-1H-azepin-1-yl)propyl]-4-(2-methylpropyl)-5-phenyl-2-oxazolidinone MLV 6976

Description	Ipenoxazone is a potent and centrally acting muscle relaxant.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vivo	Ipenoxazone is a potent and centrally acting muscle relaxant[1]. An intravenous injection of 2 mg/kg Ipenoxazone causes a reduction of electromyographic activity which reaches a maximum within 3 min after the injection. Within 1 min after the injection of Ipenoxazone at a dose of 4 mg/kg, the blood pressure changes from a control level of 138±9 mmHg to a minimum level of 98±9 mmHg (n=6) but it rapidly returns to the control level within 1 to 2 min, while the rigidity is still reduced significantly at that time. High doses (greater than 30 mg/kg i.p.) of Ipenoxazone produces a transient and dose-dependent sedation in almost all mice about 5 min after its administration[2].
Animal Admin	Experiments are performed on 31 adult male rats (Wistar 310 to 430 g, 3 to 7 months of age) anesthetized with chloralose-urethane (50 and 500 mg/kg i.p., respectively). Ipenoxazone is administrated i.v. at 0.05 to 0.1 mL/100 g body weight (20 to 40 s per injection). These four different doses of Ipenoxazone (0.3, 1, 3 and 10 mg/kg) are administrated cumulatively, from small doses to larger doses. It is usually waited about 10 to 30 min between each trial or until all effects of the drug on the bladder have disappeared[1].
References	[1]. Kimura A, et al. Inhibitory effects of a new, potent, centrally acting muscle relaxant, (4S,5R)-4-(2-methylpropyl)-3-[3-(perhydroazepin-1-yl)propyl]-5- phenyl-1,3-oxazolidin-2-one (NC-1200) on micturition contractions of the bladder in rats. Eur J Pharmacol. 1988 Jul 26;152(1-2):55-62. [2]. Masaki M, et al. A new class of potent centrally acting muscle relaxants: pharmacology of oxazolidinones in rat decerebrate rigidity. Br J Pharmacol. 1986 Sep;89(1):219-28.

Density	1.03g/cm3
Boiling Point	532.4ºC at 760 mmHg
Molecular Formula	C₂₂H₃₄N₂O₂
Molecular Weight	358.51800
Flash Point	275.8ºC
Exact Mass	358.26200
PSA	32.78000
LogP	4.73650
Vapour Pressure	2.05E-11mmHg at 25°C
Index of Refraction	1.517
Storage condition	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RQ2845020

CHEMICAL NAME :: 2-Oxazolidinone, 3-(3-(hexahydro-1H-azepin-1-yl)propyl)-4-(2-methylpro pyl)-5-phenyl-, (4S-cis)-

CAS REGISTRY NUMBER :: 104454-71-9

LAST UPDATED :: 199406

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H34-N2-O2

MOLECULAR WEIGHT :: 358.58

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 38 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 13,455,1988