5634-41-3

5634-41-3 structure

Name: parapenzolate bromide
Chemical Name: (1,1-dimethylpiperidin-1-ium-4-yl) 2-hydroxy-2,2-diphenylacetate,bromide
CAS Number: 5634-41-3
Molecular Formula: C₂₁H₂₆BrNO₃
Molecular Weight: 420.34000
Catalog: Signaling Pathways GPCR/G Protein mAChR
Create Date: 2018-03-03 08:00:00
Modify Date: 2024-01-11 12:04:31
Parapenzolate bromide, an antispasmodic, is an orally active mAChR antagonist. Parapenzolate bromide is an anticholinergic agent[1][2].

Name	(1,1-dimethylpiperidin-1-ium-4-yl) 2-hydroxy-2,2-diphenylacetate,bromide
Synonyms	Bromuro de parapenzolato Bromure de parapenzolate Parapenzolate bromide Parapenzolati bromidum Parapenzolatbromid 4-benziloyloxy-1,1-dimethyl-piperidinium,bromide 4-[2-hydroxy(diphenyl)acetoxy]-1,1-dimethylpiperidinium bromide

Description	Parapenzolate bromide, an antispasmodic, is an orally active mAChR antagonist. Parapenzolate bromide is an anticholinergic agent[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
In Vivo	Parapenzolate bromide (10 mg/kg, p.o. or i.v.) shows a significant analgesic effect in mice[1]. Parapenzolate bromide (0.5 mg/kg, i.v.) exhibits a spasmolytic activity in isolated gall bladder from guinea pigs[2]. Animal Model: Mice[1] Dosage: 10 mg/kg Administration: Oral administration (p.o.) or intravenous injection (i.v.) Result: Prolonged the time until death in convulsive mice. Animal Model: Guinea pigs[2] Dosage: 0.5 mg/kg Administration: Intravenous injection (i.v.) Result: Antagonized contractions induced by acetylcholine (100 μg/kg, i.v.)
References	[1]. Paris, J., et al. Effect of parapenzolate bromide on the contractility of the gall bladder and sphincter of Oddi. Therapie (1968), 23(3), 609-18. [2]. Ishimura Yasuko, et al. Pharmacological studies on parapenzolate bromide. 1. Pharmacological studies. Shikoku Igaku Zasshi (1970), 26(1), 43-51.