105-20-4

105-20-4 structure

Name: Betazole
Chemical Name: betazole
CAS Number: 105-20-4
Molecular Formula: C₅H₉N₃
Molecular Weight: 111.14500
Catalog: API Diagnostic medication Organ function test agent
Create Date: 2018-08-24 19:58:50
Modify Date: 2024-01-02 18:11:06
Betazole (Ametazole), a pyrazole analogue of histamine, is an orally active H2 receptor agonist. Betazole induces gastric acid secretion, and causes an immediate and significant increase in common bile duct pressure. Betazole has been used as a diagnostic agent known as histalog, for investigating gastric acid secretory capacity[1][2][3].

Name	betazole
Synonyms	2-(1(2)H-Pyrazol-3-yl)-aethylamin 3-(2-aminoethyl)pyrazole Ametazole 3-(2-Aminoethyl)-1H-pyrazole 3-(2-Aminoethyl)pyrazol 2-(1H-pyrazol-5-yl)ethanamine(SALTDATA: FREE) 2-(1(2)H-pyrazol-3-yl)-ethylamine EINECS 203-278-3

Description	Betazole (Ametazole), a pyrazole analogue of histamine, is an orally active H2 receptor agonist. Betazole induces gastric acid secretion, and causes an immediate and significant increase in common bile duct pressure. Betazole has been used as a diagnostic agent known as histalog, for investigating gastric acid secretory capacity[1][2][3].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	H2 Receptor
In Vitro	Betazole (Ametazole) is a weak histamine agonist with relative selectivity towards H2 receptors and only minimal H1 activity. Betazole induces gastric inhibitory polypeptide (GIP) secretion[1].
References	[1]. Maples MD, Effects of betazole hydrochloride and cimetidine on common bile pressure and duodenal myoelectric activity in the dog. Am Surg. 1981;47(12):519-521. [2]. Spitz IM, Betazole-induced GIP secretion is not mediated by gastric HCl. Metabolism. 1982;31(4):380-382. [3]. CLAYMAN CB,. A simple oral gastric secretory stimulant (betazole hydrochloride). JAMA. 1961;175:908-909.

HS Code	2933199090

108-97-4

105-20-4

Literature: Jones; Mann Journal of the American Chemical Society, 1953 , vol. 75, p. 4048,4050

135237-01-3

105-20-4

Literature: Jones et al. Journal of the American Chemical Society, 1949 , vol. 71, p. 4000

Precursor 2
108-97-4 135237-01-3
DownStream 0

HS Code	2933199090
Summary	2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%