Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3-demethylthiocolchicine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

87424-25-7

87424-25-7 structure

Name: 3-demethylthiocolchicine
Chemical Name: N-[(7S)-3-hydroxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
CAS Number: 87424-25-7
Molecular Formula: C₂₁H₂₃NO₅S
Molecular Weight: 401.47600
Create Date: 2016-02-06 06:43:28
Modify Date: 2024-01-17 12:35:00

Name	N-[(7S)-3-hydroxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Synonyms	N-((S)-3-Hydroxy-1,2-dimethoxy-10-methylmercapto-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamid Acetamide,N-(5,6,7,9-tetrahydro-1,2-dimethoxy-3-hydroxy-10-(methylthio)-9-oxobenzo(a)heptalen-7-yl)-,(S) 3-Desmethylthiocolchicine (S)-7-Acetylamino-3-hydroxy-1,2-dimethoxy-10-methylmercapto-6,7-dihydro-5H-benzo[a]heptalen-9-on Colchicine,O(sup 3)-demethyl-10-thio O(sup 3)-Demethyl-10-thiocolchicine Acetamide,N-((7S)-5,6,7,9-tetrahydro-3-hydroxy-1,2-dimethoxy-10-(methylthio)-9-oxobenzo(a)heptalen-7-yl) (S) N-[1,2-dimethoxy-3-hydroxy-10-methylthio-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl]-acetamide 3-demethylthiocolchicine 3-O-demethylthiocolchicine N-[(7S)-3-hydroxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide 2-Demethylthio-colchicine N-((S)-3-hydroxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide

Density	1.33g/cm3
Boiling Point	769ºC at 760 mmHg
Melting Point	>240ºC (dec.)
Molecular Formula	C₂₁H₂₃NO₅S
Molecular Weight	401.47600
Flash Point	418.9ºC
Exact Mass	401.13000
PSA	110.16000
LogP	3.67280
Index of Refraction	1.636

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC8586000

CHEMICAL NAME :: Acetamide, N-(5,6,7,9-tetrahydro-1,2-dimethoxy-3-hydroxy-10-(met hylthio)-9-oxobenzo(a) heptalen-7-yl)-, (S)-

CAS REGISTRY NUMBER :: 87424-25-7

BEILSTEIN REFERENCE NO. :: 3176383

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H23-N-O5-S

MOLECULAR WEIGHT :: 401.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 28,1204,1985

2730-71-4

~58%

87424-25-7

Literature: ALBERTA HEALTH SERVICES; NATIONAL RESEARCH COUNCIL OF CANADA; TUSZYNSKI, Jack; MANE, Jonathan Y.; HUZIL, John Torin; TOMANEK, Boguslaw; BARTUSIK, Darota Patent: WO2011/22805 A1, 2011 ; Location in patent: Page/Page column 78 ;

7336-33-6

5188-07-8

~64%

87424-25-7

Literature: Muzaffar, Anjum; Chrzanowska, Maria; Brossi, Arnold Heterocycles, 1989 , vol. 28, # 1 p. 365 - 372

602-41-5

~95%

87424-25-7

Literature: The United States of America as represented by the Department of Health and Human Services Patent: US4692463 A1, 1987 ;

51296-12-9

18107-18-1

87424-26-8

87424-25-7

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 1 p. 235 - 238

64-86-8

87424-25-7

Literature: WO2011/22805 A1, ;

74-93-1

87424-25-7

Literature: Bulletin de la Societe Chimique de France, , p. 755,756 Bulletin de la Societe Chimique de France, , p. 198

74-93-1

7336-35-8

87424-25-7

Literature: Bulletin de la Societe Chimique de France, , p. 755,756 Bulletin de la Societe Chimique de France, , p. 198

Precursor 9
602-41-5 2730-71-4 7336-33-6 5188-07-8
51296-12-9 18107-18-1 64-86-8 74-93-1
7336-35-8
DownStream 1
602-41-5

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