330936-69-1

330936-69-1 structure

Name: Humanin (human) trifluoroacetate salt
Chemical Name: Humanin
CAS Number: 330936-69-1
Molecular Formula: C₁₁₉H₂₀₄N₃₄O₃₂S₂
Molecular Weight: 2687.23000
Catalog: Signaling Pathways Apoptosis Bcl-2 Family
Create Date: 2016-05-10 23:32:17
Modify Date: 2024-01-02 17:22:15
Humanin, an anti-apoptotic peptide of 24 amino acids, is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging[1][2]. Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG[2].

Name	Humanin
Synonyms	1-24-Protein humanin (human) Protein (human clone 1 humanin sequence homolog) MET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-SER-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA MAPRGFSCLLLLTSEIDLPVKRRA

Description	Humanin, an anti-apoptotic peptide of 24 amino acids, is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging[1][2]. Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG[2].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Endocrinology Research Areas >> Neurological Disease
Target	Bax
In Vitro	Humanin (40 nM，罗丹明偶联；30 min) 抑制野生型 HCT116 细胞受 Bax 蛋白诱导的细胞死亡[1]。 Humanin (100 μM；10 min) 阻断 Bax 与分离线粒体的关联，并抑制野生型 HCT116 细胞中细胞色素 c 的释放[1]。 Humanin 减少 0.2 mM STS 诱导的细胞半凋亡[1]。 Humanin 不能抑制 Bax 缺陷的 HCT116 细胞的凋亡[1]。
In Vivo	Humanin (0.375 mg/kg/hr; 静脉注射) 增加 Zucker 糖尿病脂肪 (ZDF) 大鼠对外周胰岛素敏感性[2]。
References	[1]. Guo B, et al. Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature. 2003 May 22;423(6938):456-61. [2]. Muzumdar RH, et al. Humanin: a novel central regulator of peripheral insulin action. PLoS One. 2009 Jul 22;4(7):e6334.

Hazard Codes	Xn