67483-13-0
67483-13-0 structure
- Name: DIDS sodium salt
- Chemical Name: Benzenesulfonic acid, 2,2'-(1,2-ethenediyl)bis[5-isothiocyanato-, disodium salt
- CAS Number: 67483-13-0
- Molecular Formula: C16H8N2Na2O6S4
- Molecular Weight: 498.484
- Catalog: Dye Reagents
- Create Date: 2018-11-26 16:12:31
- Modify Date: 2024-01-07 10:59:43
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DIDS sodium salt is a dual ABCA1 and VDAC1 inhibitor.
| Name | Benzenesulfonic acid, 2,2'-(1,2-ethenediyl)bis[5-isothiocyanato-, disodium salt |
|---|---|
| Synonyms |
DisodiuM 4,4'-Diisothiocyanato-2,2'-stilbenedisulfonate
4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID DISODIUM SALT Benzenesulfonic acid, 2,2'-[(E)-1,2-ethenediyl]bis[5-isothiocyanato-, sodium salt (1:2) 4,4'-diisothiocyanato-2,2'-stilbenedisulfonic acid sodium Disodium 2,2'-[(E)-1,2-ethenediyl]bis(5-isothiocyanatobenzenesulfonate) DISODIUM 4,4'-DIISOTHIOCYANATO-2,2'-STILBENEDISULFONATE Hydrate [Protein Modification Reagent] 4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID,2NA PMPA (NMDA antagonist) Disodium 2,2'-(E)-ethene-1,2-diylbis(5-isothiocyanatobenzenesulfonate) DIDS MFCD00009638 DIDS DISODIUM SALT 4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC A. NA2-SLT HY DIDS sodium salt |
| Description | DIDS sodium salt is a dual ABCA1 and VDAC1 inhibitor. |
|---|---|
| Related Catalog | |
| Target |
ABCA1[1], VDAC1[2]. |
| In Vitro | Concentration less than 400 μM DIDS has no evident cytotoxic effect on cell viability Pre-treatment with DIDS at the concentration of 100 and 200 μM result in a prevented effect on ALA-SDT-induced cell death, while dose at 50 μM has no inhibition effect. At the concentration of 400 μM DIDS itself slightly decreases the cell viability, although there is no significant statistic difference as compared with the untreated control. Pre-treatment with DIDS (100 μM) clearly inhibit caspase-3 and caspase-9 activation[2]. |
| Cell Assay | Cells (5×105 cells/mL) are seeded in the 35-mm Petri dishes and cultured for 72 h at 37°C. Cells are pre-incubated with ALA, and then DIDS of diverse concentrations (0-200 μM) is added before exposed to ultrasound. Cell apoptosis is detected. Briefly, seeded cells (5×105 cells/mL) are pre-treated with test compounds at the indicated concentrations for 1 h (DIDS and NAC), 1.5 h (BAPTA) or with siRNA and exposed to ultrasound. Six hours after ALA-SDT treatment, cells are collected[2]. |
| References |
| Density | 1.54g/cm3 |
|---|---|
| Boiling Point | 397ºC |
| Molecular Formula | C16H8N2Na2O6S4 |
| Molecular Weight | 498.484 |
| Exact Mass | 497.906067 |
| PSA | 214.40000 |
| LogP | 5.98060 |
Synonym:4,4'-Diisothiocyanostilbene-2,2'-d-sulfonic acid disodium salt Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW
Not available. Potential Health Effects Eye: Causes eye irritation. Skin: Causes skin irritation. Ingestion: May cause irritation of the digestive tract. Inhalation: Causes respiratory tract irritation. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Antidote: None reported. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep refrigerated. (Store below 4C/39F.) Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 67483-13-0: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Powder Color: orange to tan Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: 397 deg C Freezing/Melting Point: Not available. Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: N/A Explosion Limits, upper: N/A Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C16H8N2Na2O6S4 Molecular Weight: 498.48 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, dust generation, strong oxidants. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Hydrogen cyanide, carbon monoxide, oxides of nitrogen, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Will not occur. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 67483-13-0 unlisted. LD50/LC50: Not available. Carcinogenicity: Dids - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Other No information available. Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. S 28A After contact with skin, wash immediately with plenty of water. S 37 Wear suitable gloves. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 67483-13-0: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 67483-13-0 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 67483-13-0 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A |
| Hazard Codes | Xn: Harmful; |
|---|---|
| Risk Phrases | R36/37/38 |
| Safety Phrases | 22-26 |