Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Sitaxsentan
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Huang

DC Chemicals Limited
China
Product Name: Sitaxsentan
Price: $Inquiry/250mg $Inquiry/1g $600.0/100mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Sitaxsentan
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-(4-CHLORO-3-METHYLISOXAZOL-5-YL)-2-(2-(6-METHYLBENZO[D][1,3]DIOXOL-5-YL)ACETYL)THIOPHENE-3-SULFONAMIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

184036-34-8

184036-34-8 structure

Name: sitaxsentan
Chemical Name: N-(4-Chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide
CAS Number: 184036-34-8
Molecular Formula: C₁₈H₁₅ClN₂O₆S₂
Molecular Weight: 454.90500
Catalog: Signaling Pathways GPCR/G Protein Endothelin Receptor
Create Date: 2019-01-09 19:41:50
Modify Date: 2024-01-09 04:56:02
Sitaxsentan (IPI 1040; TBC 11251) is a selective endothelin A (ETA) receptor antagonist. Antihypertensive. Sitaxsentan is used in treatment of chronic heart failure.IC50 value:Target: ETA receptor

Name	N-(4-Chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide
Synonyms	Sitaxsentan Sitax

Description	Sitaxsentan (IPI 1040; TBC 11251) is a selective endothelin A (ETA) receptor antagonist. Antihypertensive. Sitaxsentan is used in treatment of chronic heart failure.IC50 value:Target: ETA receptor
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor Research Areas >> Cardiovascular Disease
References	[1]. Chin M, Levy RD, Yoshida EM, Byrne MF.Sitaxsentan-induced acute severe hepatitis treated with glucocorticoid therapy.Can Respir J. 2012 Jan-Feb;19(1):e1-2. [2]. Sandoval J, et al. STRIDE-4 investigators.Safety and efficacy of sitaxsentan 50 and 100 mg in patients with pulmonary arterial hypertension.Pulm Pharmacol Ther. 2012 Feb;25(1):33-9. Epub 2011 Nov 2. [3]. Safdar Z. Effect of transition from sitaxsentan to ambrisentan in pulmonary arterial hypertension.Vasc Health Risk Manag. 2011;7:119-24. Epub 2011 Mar 2. [4]. Rondelet B, et al. Sildenafil added to sitaxsentan in overcirculation-induced pulmonary arterial hypertension.Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H1118-23. Epub 2010 Aug 6. [5]. Kaehler, et al. Successful treatment of portopulmonary hypertension with the selective endothelin receptor antagonist Sitaxentan. Wien Klin Wochenschr. 2011 Apr;123(7-8):248-52. Epub 2011 Mar 31.

Density	1.6g/cm3
Boiling Point	600.4ºC at 760 mmHg
Molecular Formula	C₁₈H₁₅ClN₂O₆S₂
Molecular Weight	454.90500
Flash Point	316.9ºC
Exact Mass	454.00600
PSA	144.35000
LogP	5.11500
Vapour Pressure	2.25E-14mmHg at 25°C
Index of Refraction	1.687
Storage condition	2-8℃

1008726-80-4

210421-71-9

184036-34-8

Literature: Wu, Chengde; Chan, Ming F.; Stavros, Fiona; Raju; Okun, Ilya; Mong, Seymour; Keller, Karin M.; Brock, Tommy; Kogan, Timothy P.; Dixon, Richard A. F. Journal of Medicinal Chemistry, 1997 , vol. 40, # 11 p. 1690 - 1697

117661-72-0

~69%

184036-34-8

Literature: Texas Biotechnology Corporation Patent: US6432994 B1, 2002 ; US 6432994 B1

117661-72-0

210421-71-9

184036-34-8

Literature: Chen, Jinling; Koppenol, Sandy; Rajewski, Lian; Trammel, Andrew; Amsberry, Kent; Schoeneman, Aaron Patent: US2008/76812 A1, 2008 ; Location in patent: Page/Page column 10 ;

20850-43-5

117661-72-0

210421-71-9

184036-34-8

Literature: ENCYSIVE PHARMACEUTICALS, INC. Patent: WO2007/106494 A2, 2007 ; Location in patent: Page/Page column 39-40 ;

210421-71-9

184036-34-8

Literature: Given, Bruce D.; Dixon, Richard A.F. Patent: US2008/85313 A1, 2008 ; Location in patent: Page/Page column 15 ;

117661-72-0

184040-74-2

~73%

184036-34-8

Literature: Texas Biotechnology Corp. Patent: US6342610 B2, 2002 ; Location in patent: Page column 126 ; US 6342610 B2

Precursor 4
210421-71-9 117661-72-0 20850-43-5 184040-74-2
DownStream 0