352431-28-8

352431-28-8 structure

Name: 2-(4,4,5,5-2H4)Imidazolidinethione
Chemical Name: 4,4,5,5-tetradeuterioimidazolidine-2-thione
CAS Number: 352431-28-8
Molecular Formula: C₃H₂D₄N₂S
Molecular Weight: 106.183
Catalog: Research Areas Cancer
Create Date: 2018-06-11 17:13:18
Modify Date: 2024-01-09 16:55:33
Ethylenethiourea-d4 is the deuterium labeled Ethylenethiourea[1]. Ethylenethiourea is a degradation product of the ethylenebisthiocarbamate group of fungicides. Ethylenethiourea is tumorigenic and teratogenic. Ethylenethiourea is orally active[2][3].

Name	4,4,5,5-tetradeuterioimidazolidine-2-thione
Synonyms	2-Imidazolidinethione-4,4,5,5-d 2-Imidazolidinethione-4,5-d4 1,3-Ethylenethiourea-d4 2-Imidazoline-2-thiol-d4 Mercaptoimidazoline-d4 (4,4,5,5-H)Imidazolidine-2-thione Imidazoline-2-thiol-d4 2-(4,4,5,5-H)Imidazolidinethione

Description	Ethylenethiourea-d4 is the deuterium labeled Ethylenethiourea[1]. Ethylenethiourea is a degradation product of the ethylenebisthiocarbamate group of fungicides. Ethylenethiourea is tumorigenic and teratogenic. Ethylenethiourea is orally active[2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Khera KS. Ethylenethiourea: teratogenicity study in rats and rabbits. Teratology. 1973 Jun;7(3):243-52. [3]. Graham SL, et al. Effects of one-year administration of ethylenethiourea upon the thyroid of the rat. J Agric Food Chem. 1973 May-Jun21(3):324-9.