79491-71-7

79491-71-7 structure

Name: 9-Oxo-10,11-dehydroageraphorone
Chemical Name: (4R,4aS,8aR)-1-Isopropylidene-4,7-dimethyl-1,3,4,4a,5,8a-hexahydr o-2,6-naphthalenedione
CAS Number: 79491-71-7
Molecular Formula: C₁₅H₂₀O₂
Molecular Weight: 232.32
Catalog: Natural product Sesquiter
Create Date: 2017-08-09 16:57:50
Modify Date: 2024-01-04 22:35:22
Euptox A (9-Oxo-10, 11-dehydroageraphorone), a cadenine sesquiterpene, is the main toxin that can be isolated from Eupatorium adenophorum. Euptox A induces apoptosis by improving the gene expression level of apoptotic proteases such as caspase-10 in HeLa cells[1].

Name	(4R,4aS,8aR)-1-Isopropylidene-4,7-dimethyl-1,3,4,4a,5,8a-hexahydr o-2,6-naphthalenedione
Synonyms	2,6-Naphthalenedione, 1,3,4,4a,5,8a-hexahydro-4,7-dimethyl-1-(1-methylethylidene)-, (4R,4aS,8aR)- (4R,4aS,8aR)-1-Isopropylidene-4,7-dimethyl-1,3,4,4a,5,8a-hexahydro-2,6-naphthalenedione

Description	Euptox A (9-Oxo-10, 11-dehydroageraphorone), a cadenine sesquiterpene, is the main toxin that can be isolated from Eupatorium adenophorum. Euptox A induces apoptosis by improving the gene expression level of apoptotic proteases such as caspase-10 in HeLa cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Apoptosis >> Caspase
In Vitro	Euptox A (0-2 μg/mL, 48 h) 有效抑制HeLa细胞增殖[1]。 Euptox A（0-50 μg/mL，24 小时）阻止细胞周期从 S 期到 G2/M 期的转变[1]。 Euptox A 在体外以剂量依赖的方式对人肺癌 A549、HeLa 和 Hep-2 细胞系表现出显着的抗肿瘤活性[1]。 Euptox A 在体外对 S.scabiei 和P. cuniculi 表现出高度杀螨活性[1]。
References	[1]. Liao F, et al. Induction and mechanism of HeLa cell apoptosis by 9-oxo‑10, 11-dehydroageraphorone from Eupatorium adenophorum. Oncol Rep. 2015 Apr;33(4):1823-7.

Hazard Codes	Xi