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146478-72-0

146478-72-0 structure
146478-72-0 structure
  • Name: FR901464
  • Chemical Name: fr901464
  • CAS Number: 146478-72-0
  • Molecular Formula: C27H41NO8
  • Molecular Weight: 507.61600
  • Catalog: Research Areas Cancer
  • Create Date: 2017-01-02 18:44:02
  • Modify Date: 2024-01-11 17:35:04
  • FR901464 is a potent spliceosome inhibitor with prominent anti-tumor and anti-cancer effects[1].
Name fr901464
Synonyms WB 2663B
[(E,2S)-5-[[(2R,5S,6S)-6-[(2E,4E)-5-[(4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]octan-5-yl]-3-methylpenta-2,4-dienyl]-2,5-dimethyloxan-3-yl]amino]-5-oxopent-3-en-2-yl] acetate
[(E,2S)-5-[[(2R,5S,6S)-6-[(2E,4E)-5-[(5S,7R,8R)-5,8-dihydroxy-5-methyl-2,6-dioxaspiro[2.5]octan-7-yl]-3-methylpenta-2,4-dienyl]-2,5-dimethyloxan-3-yl]amino]-5-oxopent-3-en-2-yl] acetate
Description FR901464 is a potent spliceosome inhibitor with prominent anti-tumor and anti-cancer effects[1].
Related Catalog
In Vitro FR901464 (10-20 ng/ml; 6-24 hours) inhibits the growth of murine solid tumors, Colon 38 carcinoma and Meth A fibrosarcoma. FR901464 induces characteristic G1 and G2/M phase arrest in the cell cycle and internucleosomal degradation of genomic DNA with the same kinetics as activation of SV40 promoter-dependent cellular transcription in M-8 tumor cells[1]. FR901464 (1-10 ng/ml; 16 hours) suppresses the transcription of some inducible endogenous genes but not house keeping genes in M-8 cells[1]. FR901464 exhibits potent anticancer activity. It shows enhancement of activity of a promoter of the SV40 DNA tumor virus at 10 nM concentration in M-8 cells[1].
References

[1]. H Nakajima, et al. New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action. J Antibiot (Tokyo). 1996 Dec;49(12):1204-11.

[2]. Arun K Ghosh, et al. Enantioselective total syntheses of FR901464 and spliceostatin A and evaluation of splicing activity of key derivatives. J Org Chem. 2014 Jun 20;79(12):5697-709.
Density 1.21g/cm3
Boiling Point 702.7ºC at 760mmHg
Molecular Formula C27H41NO8
Molecular Weight 507.61600
Flash Point 378.8ºC
Exact Mass 507.28300
PSA 130.34000
LogP 3.15270
Vapour Pressure 7.94E-23mmHg at 25°C
Index of Refraction 1.553

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ZC0702750
CHEMICAL NAME :
WB 2663B
CAS REGISTRY NUMBER :
146478-72-0
LAST UPDATED :
199806
DATA ITEMS CITED :
1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 49,1196,1996
Hazard Codes Xi

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title: CAS No. 146478-72-0 | Chemsrc address: https://www.chemsrc.com/en/baike/525573.html

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