119662-55-4

119662-55-4 structure

Name: BiCAPPA
Chemical Name: 6-chloro-N-[3-[4-[3-[(6-chloro-2-methoxyacridin-9-yl)amino]propyl]piperazin-1-yl]propyl]-2-methoxyacridin-9-amine
CAS Number: 119662-55-4
Molecular Formula: C₃₈H₄₀Cl₂N₆O₂
Molecular Weight: 683.66900
Catalog: Research Areas Infection
Create Date: 2016-04-27 03:21:46
Modify Date: 2024-01-08 11:29:34
BiCAPPA is the first bivalent antiprion ligand. BiCAPPA can decrease infectious conformational form of prion protein (PrPSc) from scrapie-infected cells, with an EC50 of 0.32 μM[1][2].

Name	6-chloro-N-[3-[4-[3-[(6-chloro-2-methoxyacridin-9-yl)amino]propyl]piperazin-1-yl]propyl]-2-methoxyacridin-9-amine
Synonyms	BiCAPPA N,N inverted exclamation marka-Bis(6-chloro-2-methoxy-9-acridinyl)-1,4-piperazinedipropanamine N,N'-Bis(6-chloro-2-methoxy-9-acridinyl)-1,4-piperazinedipropanamine

Description	BiCAPPA is the first bivalent antiprion ligand. BiCAPPA can decrease infectious conformational form of prion protein (PrPSc) from scrapie-infected cells, with an EC50 of 0.32 μM[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
In Vitro	BiCAPPA (10 nM-2 μM; 5 d) 降低感染痒病的小鼠下丘脑细胞的蛋白酶 K 抗性 PrPSc，EC50 值为 0.32 μM [2]。
References	[1]. Uliassi E, et, al. 10-Medicinal Chemistry of Hybrids for Neurodegenerative Diseases. Design of Hybrid Molecules for Drug Development. 2017, Pages 259-277. [2]. Bongarzone S, et, al. Parallel synthesis, evaluation, and preliminary structure-activity relationship of 2,5-diamino-1,4-benzoquinones as a novel class of bivalent anti-prion compound. J Med Chem. 2010 Nov 25;53(22):8197-201.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26
RIDADR	NONH for all modes of transport