BiCAPPA
Modify Date: 2024-01-08 11:29:34
BiCAPPA structure
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Common Name | BiCAPPA | ||
|---|---|---|---|---|
| CAS Number | 119662-55-4 | Molecular Weight | 683.66900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C38H40Cl2N6O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of BiCAPPABiCAPPA is the first bivalent antiprion ligand. BiCAPPA can decrease infectious conformational form of prion protein (PrPSc) from scrapie-infected cells, with an EC50 of 0.32 μM[1][2]. |
| Name | 6-chloro-N-[3-[4-[3-[(6-chloro-2-methoxyacridin-9-yl)amino]propyl]piperazin-1-yl]propyl]-2-methoxyacridin-9-amine |
|---|---|
| Synonym | More Synonyms |
| Description | BiCAPPA is the first bivalent antiprion ligand. BiCAPPA can decrease infectious conformational form of prion protein (PrPSc) from scrapie-infected cells, with an EC50 of 0.32 μM[1][2]. |
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| Related Catalog | |
| In Vitro | BiCAPPA (10 nM-2 μM; 5 d) 降低感染痒病的小鼠下丘脑细胞的蛋白酶 K 抗性 PrPSc，EC50 值为 0.32 μM [2]。 |
| References |
| Molecular Formula | C38H40Cl2N6O2 |
|---|---|
| Molecular Weight | 683.66900 |
| Exact Mass | 682.25900 |
| PSA | 81.24000 |
| LogP | 7.05480 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26 |
| RIDADR | NONH for all modes of transport |
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Protein aggregation and neurodegenerative disease.
Nat. Med. 10 Suppl , S10-S17 , (2004) Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and prion diseases are increasingly being realized... |
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Potent inhibition of scrapie prion replication in cultured cells by bis-acridines.
Proc. Natl. Acad. Sci. U. S. A. 100 , 3416-3421, (2003) Prion diseases are characterized by an accumulation of PrP(Sc), a misfolded isoform of the normal cellular prion protein, PrP(C). We previously reported the bioactivity of acridine-based compounds aga... |
| BiCAPPA |
| N,N inverted exclamation marka-Bis(6-chloro-2-methoxy-9-acridinyl)-1,4-piperazinedipropanamine |
| N,N'-Bis(6-chloro-2-methoxy-9-acridinyl)-1,4-piperazinedipropanamine |