107729-45-3

107729-45-3 structure

Name: SF 2312
Chemical Name: (1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid
CAS Number: 107729-45-3
Molecular Formula: C₄H₈NO₆P
Molecular Weight: 197.08300
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2017-05-10 11:07:08
Modify Date: 2024-01-16 13:34:12
SF2312, a natural phosphonate Antibiotic (Antibiotic), is a highly potent Enolase (Enolase) inhibitor with IC50s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively. SF2312 is active against bacteria under anaerobic conditions[1].

Name	(1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid

Description	SF2312, a natural phosphonate Antibiotic (Antibiotic), is a highly potent Enolase (Enolase) inhibitor with IC50s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively. SF2312 is active against bacteria under anaerobic conditions[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Enolase Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	SF2312 对 ENO1 缺失的神经胶质瘤细胞具有选择性毒性。SF2312 在低 μM 范围内抑制 ENO1 缺失的 D423 神经胶质瘤细胞系的增殖 (处理 2 周)，而同基因 ENO1 拯救的 D423 细胞，异位再表达 ENO1 仅在 SF2312 浓度高于 200 μM 时显示增殖抑制。SF2312 (10 μM) 以剂量依赖性方式减少 U-13C 葡萄糖向 13C 乳酸的转化，其方式对 ENO1 缺失优于 ENO1 拯救或其他 ENO1 -完整的神经胶质瘤细胞[1]。 SF2312 由放线菌小单孢菌产生，对多种细菌均有活性，对沙门氏菌和葡萄球菌活性强，对大肠杆菌活性弱，对真菌无活性[1]。
References	[1]. Paul G Leonard, et al. SF2312 is a natural phosphonate inhibitor of enolase. Nat Chem Biol. 2016 Dec;12(12):1053-1058.