109351-36-2
109351-36-2 structure
- Name: Sinococuline
- Chemical Name: Sinococuline
- CAS Number: 109351-36-2
- Molecular Formula: C18H23NO5
- Molecular Weight: 333.37900
- Catalog: Signaling Pathways Anti-infection Influenza Virus
- Create Date: 2017-01-14 08:13:48
- Modify Date: 2024-01-28 20:38:14
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Sinococuline is a potent anti-dengue agent that is effective against all four serotypes of dengue virus (DENV). Sinococuline is also an effective tumor cell growth inhibitor[1][2].
| Name | Sinococuline |
|---|---|
| Synonyms |
Morphinan-4,6,7-triol,8,14-didehydro-3,8-dimethoxy-,(6beta,7beta,9alpha,13alpha)
(6beta,7beta,9alpha,13alpha)-8,14-Didehydro-3,8-dimethoxymorphinan-4,6,7-triol 4,6,7-trihydroxy-8,14-didehydro-3,8-dimethoxy-morphinan |
| Description | Sinococuline is a potent anti-dengue agent that is effective against all four serotypes of dengue virus (DENV). Sinococuline is also an effective tumor cell growth inhibitor[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Sinococuline (0.5-5.0 μg/mL; 6 days) 抑制 DENV-2 感染的 Vero 细胞释放非结构蛋白-1 (NS1)[1]。 Sinococuline (0-40 μg/mL; 48 h) 抑制 Vero 细胞中的泛 DENV 感染，对 DENV-1，DENV-2，DENV-3 和 DENV-4 的 IC50 值分别为 0.2，0.08，0.17 和 0.1 μg/mL [1]。 |
| In Vivo | Sinococuline (0.5-2.0 mg/kg/day; i.p. twice a day for 5 days) 可降低严重 DENV 感染的 AG129 小鼠的发病率并提高其存活率，且不影响动物体重[1]。 Animal Model: AG129 mouse (an interferon type I and II receptor-deficient mice) with severe DENV-infection[1] Dosage: 0.5, 1.0, 2.0 mg/kg/day Administration: I.p. twice a day for 5 days Result: Showed delayed mortality and survived significantly of mice, but none of the mice could survive till the end of experiment at the dose of 0.5 mg/kg/day. The mice completely survived through the entire course of experiment at the dose of 2.0 mg/kg/day. |
| References |
[2]. Liu WK, et, al. Cytotoxic effects of sinococuline. Cancer Lett. 1996 Feb 6;99(2):217-24. |
| Density | 1.41g/cm3 |
|---|---|
| Boiling Point | 562.7ºC at 760mmHg |
| Molecular Formula | C18H23NO5 |
| Molecular Weight | 333.37900 |
| Flash Point | 294.1ºC |
| Exact Mass | 333.15800 |
| PSA | 91.18000 |
| LogP | 0.91140 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.66 |
| Precursor 1 | |
|---|---|
| DownStream 0 | |