124020-27-5

124020-27-5 structure

Name: Levosulpiride-d3
Chemical Name: N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-5-sulfamoyl-2-(trideuteriomethoxy)benzamide
CAS Number: 124020-27-5
Molecular Formula: C₁₅H₂₀D₃N₃O₄S
Molecular Weight: 344.44400
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2017-02-27 22:24:39
Modify Date: 2024-01-18 08:37:41
Levosulpiride-d3 (RV-12309-d3) is the deuterium labeled Levosulpiride. Levosulpiride (RV-12309) is the (S)-enantiomer of sulpiride, which is a D2 receptor a antagonist, an atypical antipsychotic drug of the benzamide class[1][2].

Name	N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-5-sulfamoyl-2-(trideuteriomethoxy)benzamide
Synonyms	S-Sulpiride-d3 Levopraid-d3 Levosulpiride-d3 L-Sulpiride-d3 Sulpid-d3 Levopride-d3 Levobren-d3 (-)-N-[(1-Ethyl-2-pyrrolidinyl)methyl]-5-sulfamoyl-o-anisamide-d3 (-)-Sulpiride-d3

Description	Levosulpiride-d3 (RV-12309-d3) is the deuterium labeled Levosulpiride. Levosulpiride (RV-12309) is the (S)-enantiomer of sulpiride, which is a D2 receptor a antagonist, an atypical antipsychotic drug of the benzamide class[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Triebel J, et al. From Bench to Bedside: Translating the Prolactin/Vasoinhibin Axis. Front Endocrinol (Lausanne). 2017;8:342. Published 2017 Dec 11.