2345-17-7

2345-17-7 structure

Name: Irisolidone
Chemical Name: 5,7-dihydroxy-6-methoxy-3-(4-methoxyphenyl)chromen-4-one
CAS Number: 2345-17-7
Molecular Formula: C₁₇H₁₄O₆
Molecular Weight: 314.28900
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Chloride Channel
Create Date: 2017-04-01 13:13:21
Modify Date: 2024-01-02 23:04:43
Irisolidone is a major isoflavone found in Pueraria lobata flowers. Irisolidone exhibits potent hepatoprotective activity. Irisolidone shows the high efficacy for volume-regulated anion channels (VRAC) blockade[1][2][3].

Name	5,7-dihydroxy-6-methoxy-3-(4-methoxyphenyl)chromen-4-one
Synonyms	Irisolidone 4',6-dimethoxy-5,7-dihydroxyisoflavone 5,7-dihydroxy-6,4'-dimethoxyisoflavone 4'-O-Methyltectorigenin 4'-methoxytectorigenin

Description	Irisolidone is a major isoflavone found in Pueraria lobata flowers. Irisolidone exhibits potent hepatoprotective activity. Irisolidone shows the high efficacy for volume-regulated anion channels (VRAC) blockade[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel Research Areas >> Neurological Disease
In Vitro	Irisolidone shows the high efficacy for Volume-regulated anion channels (VRAC) blockade with an IC50 of 9.8 μM in HEK293 cells[3]. Irisolidone can inhibit endothelial cell proliferation[3].
References	[1]. Kim SY, et al. Irisolidone, an isoflavone metabolite, represses JC virus gene expression via inhibition of Sp1 binding in human glial cells. Biochem Biophys Res Commun. 2006 May 26;344(1):3-8. [2]. Zhang G, et al. Pharmacokinetics of irisolidone and its main metabolites in rat plasma determined by ultra performance liquid chromatography/quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Nov 15;1005:23-9. [3]. Xue Y, et al. Natural and synthetic flavonoids, novel blockers of the volume-regulated anion channels, inhibit endothelial cell proliferation. Pflugers Arch. 2018 Oct;470(10):1473-1483.

Density	1.402g/cm3
Boiling Point	565.5ºC at 760mmHg
Melting Point	192 ºC (methanol )
Molecular Formula	C₁₇H₁₄O₆
Molecular Weight	314.28900
Flash Point	212.3ºC
Exact Mass	314.07900
PSA	89.13000
LogP	2.88840
Vapour Pressure	2.15E-13mmHg at 25°C
Index of Refraction	1.645
Storage condition	2-8℃
Water Solubility	Practically insoluble (0.05 g/L) (25 ºC)

HS Code	2914509090

204590-55-6

2345-17-7

Literature: Horie, Tokunaru; Shibata, Kenichi; Yamashita, Kazuyo; Fujii, Kenichi; Tsukayama, Masao; Ohtsuru, Yoshizumi Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 2 p. 222 - 230

6009-88-7

2345-17-7

Literature: Mannich et al. Archiv der Pharmazie (Weinheim, Germany), 1937 , vol. 275, p. 317,326

53505-61-6

2345-17-7

Literature: Horie, Tokunaru; Shibata, Kenichi; Yamashita, Kazuyo; Fujii, Kenichi; Tsukayama, Masao; Ohtsuru, Yoshizumi Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 2 p. 222 - 230

204591-53-7

2345-17-7

Literature: Horie, Tokunaru; Shibata, Kenichi; Yamashita, Kazuyo; Fujii, Kenichi; Tsukayama, Masao; Ohtsuru, Yoshizumi Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 2 p. 222 - 230

611-40-5

2345-17-7

Literature: Mannich et al. Archiv der Pharmazie (Weinheim, Germany), 1937 , vol. 275, p. 317,326

Precursor 2
6009-88-7 611-40-5
DownStream 3
548-77-6 13539-26-9 4332-73-4

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

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