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1025504-45-3

1025504-45-3 structure
1025504-45-3 structure
  • Name: Valbenazine
  • Chemical Name: [(2R,3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl] (2S)-2-amino-3-methylbutanoate
  • CAS Number: 1025504-45-3
  • Molecular Formula: C24H38N2O4
  • Molecular Weight: 418.569
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2017-08-01 21:55:37
  • Modify Date: 2024-01-03 12:21:04
  • Valbenazine is a prodrug of the (+)-α isomer of tetrabenazine for tardive syndrome therapy, and inhibits VMAT2 function.

Name [(2R,3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl] (2S)-2-amino-3-methylbutanoate
Synonyms Ingrezza
(2R,3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl L-valinate
NBI-98854
L-Valine, (2R,3R,11bR)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-yl ester
UNII:54K37P50KH
(2R,3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-benzo[a]quinolizin-2-yl L-valinate
Valbenazine
Description Valbenazine is a prodrug of the (+)-α isomer of tetrabenazine for tardive syndrome therapy, and inhibits VMAT2 function.
Related Catalog
In Vivo Valbenazine shows a distinctive improvement in tardive dyskinesia symptoms during the successful Phase II trial[1].
References

[1]. Müller T, et al. Valbenazine granted breakthrough drug status for treating tardive dyskinesia. Expert Opin Investig Drugs. 2015 Jun;24(6):737-42.

Density 1.1±0.1 g/cm3
Boiling Point 507.2±50.0 °C at 760 mmHg
Molecular Formula C24H38N2O4
Molecular Weight 418.569
Flash Point 260.6±30.1 °C
Exact Mass 418.283173
PSA 74.02000
LogP 4.31
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.548
Storage condition 2-8℃