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109760-77-2

109760-77-2 structure
109760-77-2 structure
  • Name: D,L-erythro-PDMP
  • Chemical Name: d,l-erythro-1-phenyl-2-decanoylamino-3-morpholino-1-propanol hcl
  • CAS Number: 109760-77-2
  • Molecular Formula: C23H38N2O3
  • Molecular Weight: 390.56
  • Catalog: Research Areas Others
  • Create Date: 2016-02-10 09:09:50
  • Modify Date: 2024-01-16 14:05:23
  • D,L-erythro-PDMP is a erythro isomer of glucosylceramide synthase inhibitor[1][2].
Name d,l-erythro-1-phenyl-2-decanoylamino-3-morpholino-1-propanol hcl
Synonyms d,l-erythro-pdmp
Description D,L-erythro-PDMP is a erythro isomer of glucosylceramide synthase inhibitor[1][2].
Related Catalog
In Vitro D,L-erythro-PDMP (0, 12, 25, 50 μM; 0, 4, 7, 10 days) shows a inhibitory effect on cell growth of rabbit skin fibroblasts[1]. D,L-erythro PDMP (50 μM; 3 days) has eytotoxic of rabbit skin fibroblasts on cell morphology[1]. D,L-erythro-PDMP do not affect the biosynthesis of glycosphingolipids[1]. D,L-erythro-PDMP (MDCK cells; 40 μM; 24 h) induces a marked increase in glucosyltransferase specific activity: 14.6 nmol/h per mg protein[2]. D,L-erythro-PDMP (40 μM; 6 h) protects the cells against loss of synthase in cells exposes to cycloheximide[2]. Cell Proliferation Assay[1] Cell Line: rabbit skin fibroblast Concentration: 0, 12, 25, 50 μM Incubation Time: 0, 4, 7, 10 days Result: Showed a inhibitory effect on cell growth. Cell Cytotoxicity Assay[1] Cell Line: rabbit skin fibroblast Concentration: 50 μM Incubation Time: 3 days Result: Had eytotoxic on cell morphology.
References

[1]. [1] Uemura K, et al. Effect of an inhibitor of glucosylceramide synthesis on cultured rabbit skin fibroblasts. J Biochem. 1990 Oct;108(4):525-30.

[2]. [2] Abe A, et al. Induction of glucosylceramide synthase by synthase inhibitors and ceramide. Biochim Biophys Acta. 1996 Feb 16;1299(3):333-41.
Molecular Formula C23H38N2O3
Molecular Weight 390.56
Exact Mass 426.26500
PSA 61.80000
LogP 4.80850
Hazard Codes Xi

Chemsrc provides CAS#:109760-77-2 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 109760-77-2 | Chemsrc address: https://www.chemsrc.com/en/baike/584324.html

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