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DC Chemicals Limited
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Fotemustine
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Dayang Chem (Hangzhou) Co., Ltd.
China
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92118-27-9

92118-27-9 structure

92118-27-9 structure

Name: Fotemustine
Chemical Name: Diethyl (1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate
CAS Number: 92118-27-9
Molecular Formula: C₉H₁₉ClN₃O₅P
Molecular Weight: 315.691
Catalog: API Antineoplastic agents Alkylating agent
Create Date: 2018-05-03 08:00:00
Modify Date: 2024-01-05 12:31:23
Fotemustine is a DNA-alkylating agent, with antitumor activity.

Name	Diethyl (1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate
Synonyms	Phosphonic acid, P-[1-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]ethyl]-, diethyl ester MFCD00866278 Diethyl (1-{[(2-chloroethyl)(nitroso)carbamoyl]amino}ethyl)phosphonate 1-(2-chloroethyl)-3-(1-diethoxyphosphorylethyl)-1-nitrosourea Fotemustine

Description	Fotemustine is a DNA-alkylating agent, with antitumor activity.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker Research Areas >> Cancer
Target	DNA Alkylator[1]
In Vitro	Fotemustine is a DNA-alkylating agent. Fotemustine (800 μM) decreases GSH and intracellular GSSG levels but increases the extracellular GSSG-levels rapidly in isolated rat hepatocytes[1]. Fotemustine shows inhibitory effect on several tumor cell lines, with IC50s ranging form 0.05 to 0.18 mM[2].
Cell Assay	Cell proliferation assays are performed using MTT. Briefly, cell suspensions containing 2 × 104 viable cells/mL are plated into 96-well dishes and allowed to attach for 48 h at 371C in a 5% CO2 atmosphere. The culture medium is then removed and the cells are incubated for two doubling times at 37°C in the culture medium containing fotemustine (10-3 to 10 mM). When tested, amifostine or WR-1065 (10-4 to 10 mM) is added before Fotemustine for 15 min. Control cultures are exposed to saline for 15 min and then allowed to grow for the same duration in complete culture medium[2].
References	[1]. Brakenhoff JP, et al. Molecular mechanisms of toxic effects of fotemustine in rat hepatocytes and subcellular rat liver fractions. Carcinogenesis. 1996 Apr;17(4):715-24. [2]. Merlin JL, et al. Enhancement of fotemustine (Muphoran) cytotoxicity by amifostine in malignant melanoma cell lines. Anticancer Drugs. 2002 Feb;13(2):141-7.

Density	1.4±0.1 g/cm3
Boiling Point	188 °C(lit.)
Melting Point	85ºC
Molecular Formula	C₉H₁₉ClN₃O₅P
Molecular Weight	315.691
Flash Point	104 °F
Exact Mass	315.075073
PSA	107.11000
LogP	1.26
Index of Refraction	1.524
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SZ7115500

CHEMICAL NAME :: Phosphonic acid, (1-((((2-chloroethyl)nitrosoamino)carbonyl)amino)ethy l)-, diethyl ester

CAS REGISTRY NUMBER :: 92118-27-9

LAST UPDATED :: 199410

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C9-H19-Cl-N3-O5-P

MOLECULAR WEIGHT :: 315.73

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 5 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 286,101,1993

Symbol	GHS08
Signal Word	Warning
Hazard Statements	H351
Precautionary Statements	P281
Hazard Codes	Xi
Risk Phrases	R10:Flammable. R36/37:Irritating to eyes and respiratory system . R43:May cause sensitization by skin contact.
Safety Phrases	S16-S26-S36
RIDADR	UN 3336 3/PG 2
WGK Germany	3
Packaging Group	III
Hazard Class	6.1(b)