Shanghai Nianxing Industrial Co., Ltd
China
Product Name: U18666A
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

ShangHai DC Chemicals Co.,Ltd
China
Product Name: U18666A
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

DC Chemicals Limited
China
Product Name: U18666A
Price: $650.0/100mg $1300.0/250mg $2600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Androst-5-en-17-one,3-[2-(diethylamino)ethoxy]-, hydrochloride (1:1), (3b)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

3039-71-2

3039-71-2 structure

3039-71-2 structure

Name: U-18666A
Chemical Name: (3S,8R,9S,10R,13S,14S)-3-[2-(diethylamino)ethoxy]-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one,hydrochloride
CAS Number: 3039-71-2
Molecular Formula: C₂₅H₄₂ClNO₂
Molecular Weight: 424.060
Catalog: Research Areas Infection
Create Date: 2017-07-05 13:50:27
Modify Date: 2024-01-06 07:52:45
U18666A, a cell permeable drug, is a cholesterol synthesis and transport inhibitor.

Name	(3S,8R,9S,10R,13S,14S)-3-[2-(diethylamino)ethoxy]-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one,hydrochloride
Synonyms	Androst-5-en-17-one, 3-[2- (diethylamino)ethoxy]-, hydrochloride, (3β)- (3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride (1:1) Androst-5-en-17-one, 3β-(2-(diethylamino)ethoxy)-, hydrochloride (8CI) Androst-5-en-17-one, 3β-[2- (diethylamino)ethoxy]-, hydrochloride Androst-5-en-17-one, 3-(2-(diethylamino)ethoxy)-, hydrochloride, (3β)- Androst-5-en-17-one, 3-[2-(diethylamino)ethoxy]-, (3β)-, hydrochloride (1:1)

Description	U18666A, a cell permeable drug, is a cholesterol synthesis and transport inhibitor.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease Research Areas >> Infection
Target	Cholesterol[1][2].
In Vitro	U18666A, the antiviral effect is found to result from two events: retarded viral trafficking in the cholesterol-loaded late endosomes/lysosomes and suppresse de novo sterol biosynthesis in treated infected cells. It is also observed an additive antiviral effect of U18666A with C75, a fatty acid synthase inhibitor, suggesting dengue virus relies on both the host cholesterol and fatty acid biosynthesis for successful replication[1][2].
References	[1]. Poh MK, et al. U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication. Antiviral Res. 2012 Jan;93(1):191-8. [2]. Cenedella RJ, et al. Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes. Lipids. 2009 Jun;44(6):477-87.

Molecular Formula	C₂₅H₄₂ClNO₂
Molecular Weight	424.060
Exact Mass	423.290405
PSA	29.54000
LogP	6.04730
Storage condition	2-8℃

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport