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53251-94-8

53251-94-8 structure
53251-94-8 structure
  • Name: L-Pinaverium bromide
  • Chemical Name: 4-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2-(6,6-dimethyl-4-bicyclo[3.1.1]heptanyl)ethoxy]ethyl]morpholin-4-ium,bromide
  • CAS Number: 53251-94-8
  • Molecular Formula: C26H41Br2NO4
  • Molecular Weight: 591.416
  • Catalog: API Anesthetic Agents Skeletal muscle relaxant
  • Create Date: 2018-08-12 18:32:31
  • Modify Date: 2024-01-04 12:24:34
  • Pinaverium bromide is an L-type calcium channel blocker with selectivity for the gastrointestinal tract, effectively relieves pain, diarrhea and intestinal discomfort, provides good therapeutic efficacies without significant adverse effects on Irritable bowel syndrome (IBS) patients[1].
Name 4-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2-(6,6-dimethyl-4-bicyclo[3.1.1]heptanyl)ethoxy]ethyl]morpholin-4-ium,bromide
Synonyms 4-(6-Bromoveratryl)-4-[2-[2-(6,6-dimethyl-2-norpinyl)ethoxy]ethyl]morpholinium Bromide
LAT 1717
Dicetel
EINECS 258-450-0
Pinaverium bromide
UNII-7SCF54H12J
Morpholinium, 4-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)ethoxy]ethyl]-, bromide (1:1)
4-(2-Bromo-4,5-dimethoxybenzyl)-4-{2-[2-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)ethoxy]ethyl}morpholin-4-ium bromide
4-[(2-Bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)ethoxy]ethyl]morpholinium Bromide
Description Pinaverium bromide is an L-type calcium channel blocker with selectivity for the gastrointestinal tract, effectively relieves pain, diarrhea and intestinal discomfort, provides good therapeutic efficacies without significant adverse effects on Irritable bowel syndrome (IBS) patients[1].
Related Catalog
Target

Calcium channel[1].

References

[1]. Dai Y, et al. Effect of pinaverium bromide on stress-induced colonic smooth muscle contractility disorder in rats. World J Gastroenterol. 2003 Mar;9(3):557-61.
Melting Point 159-164ºC
Molecular Formula C26H41Br2NO4
Molecular Weight 591.416
Exact Mass 589.140198
PSA 36.92000
LogP 2.25510
Storage condition -20°C Freezer

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QF2810000
CHEMICAL NAME :
Morpholinium, 4-(2-bromo-4,5-dimethoxy)benzyl-4-(2-(2-(6,6-dimethyl -2-norpinyl)ethoxy) ethyl)-, bromide
CAS REGISTRY NUMBER :
53251-94-8
LAST UPDATED :
199109
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C26-H41-Br-N-O4.Br
MOLECULAR WEIGHT :
591.50
WISWESSER LINE NOTATION :
L46 ATJ A1 A1 E2O2- AT6K DOTJ A1R BE DO1 EO1 &E &24/47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
504 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 40,133,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
37 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 9,182,1974
Precursor  2

DownStream  0


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