1553-56-6

1553-56-6 structure

Name: 3-Oxo-5β-cholanoic acid
Chemical Name: 3-oxo-5β-cholanic acid
CAS Number: 1553-56-6
Molecular Formula: C₂₄H₃₈O₃
Molecular Weight: 374.55700
Catalog: Signaling Pathways Metabolic Enzyme/Protease ROR
Create Date: 2016-07-23 19:14:49
Modify Date: 2024-01-05 22:59:05
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid), a bile acid metabolite, inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd=1.13 μM)[1].

Name	3-oxo-5β-cholanic acid
Synonyms	3-oxo-5beta-cholanic acid 3-oxocholanic acid DEHYDROLITHOCHOLIC ACID

Description	3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid), a bile acid metabolite, inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd=1.13 μM)[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> ROR Research Areas >> Inflammation/Immunology
In Vitro	Treatment with 3-Oxo-5β-cholanoic acid significantly reduced the activity of the RORγt reporter. These data suggest that 3-Oxo-5β-cholanoic acid probably inhibits TH17 cell differentiation by physically interacting with RORγt, and inhibiting its transcriptional activity[1].
In Vivo	3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (0.3% (w/w); p.o.; for 1 week) significantly reduces the percentage of ileal TH17 cells[1]. Animal Model: B6 Jax mice (with a faecal slurry containing SFB)[1] Dosage: 0.3% (w/w) Administration: Gavaged; for 1 week Result: Significantly reduced the percentage of ileal TH17 cells.
References	[1]. Hang S, et al. Bile acid metabolites control TH17 and Treg cell differentiation. Nature. 2019 Dec;576(7785):143-148.

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 4,1179,1983

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Literature: Nahar, Lutfun; Turner, Alan B. Journal of Chemical Research, 2004 , # 5 p. 329 - 332

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Literature: Faarup, Peter Patent: US2002/183531 A1, 2002 ;

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