438-67-5

438-67-5 structure

Name: Estrone sulfate sodium
Chemical Name: estrone sodium sulfate
CAS Number: 438-67-5
Molecular Formula: C₁₈H₂₁NaO₅S
Molecular Weight: 372.41
Catalog: Research Areas Cancer
Create Date: 2018-07-25 10:27:38
Modify Date: 2024-01-08 12:44:45
Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). strone sulfate can be used for the research of breast cancer[1][2].

Name	estrone sodium sulfate
Synonyms	Estra-1(10),2,4-trien-17-one, 3-(sulfooxy)-, sodium salt (1:1) Sodium 17-oxoestra-1(10),2,4-trien-3-yl sulfate Estrone 3-sulfate sodium salt Estrone sodium sulfate Estrone sulfate sodium Estrone-3-sulfate sodium salt estrone sodium sulphate Sodium estrone 3-sulfate

Description	Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). strone sulfate can be used for the research of breast cancer[1][2].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer
Target	Human Endogenous Metabolite
In Vitro	T47D cells are stably transfected with SOAT and incubated under increasing concentrations of Estrone sulfate and estradiol at physiologically relevant concentrations. Cell proliferation is significantly increased by 1 nM estradiol as well as by Estrone sulfate with EC50 of 2.2 nM[3].
References	[1]. Nakamura Y, et al. Steroid sulfatase and estrogen sulfotransferase in the atherosclerotic human aorta. Am J Pathol. 2003;163(4):1329-1339. [2]. Duncan L, et al. Inhibition of estrone sulfatase activity by estrone-3-methylthiophosphonate: a potential therapeutic agent in breast cancer. Cancer Res. 1993;53(2):298-303. [3]. Karakus E, et al. Estrone-3-Sulfate Stimulates the Proliferation of T47D Breast Cancer Cells Stably Transfected With the Sodium-Dependent Organic Anion Transporter SOAT (SLC10A6). Front Pharmacol. 2018;9:941. Published 2018 Aug 21.

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 55,191,1979

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H315-H319-H335-H350
Precautionary Statements	P201-P261-P305 + P351 + P338-P308 + P313
Hazard Codes	T: Toxic;
Risk Phrases	R45-36/37/38
Safety Phrases	S53-45-26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	KG8775000