135661-44-8
135661-44-8 structure
- Name: Sulfosuccinimidyl oleate
- Chemical Name: 1-octadec-9-enoyloxy-2,5-dioxopyrrolidine-3-sulfonic acid,sodium
- CAS Number: 135661-44-8
- Molecular Formula: C22H36NNaO7S
- Molecular Weight: 481.57900
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2016-10-29 10:09:42
- Modify Date: 2024-01-03 19:43:56
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Sulfosuccinimidyl oleate is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect[1].
| Name | 1-octadec-9-enoyloxy-2,5-dioxopyrrolidine-3-sulfonic acid,sodium |
|---|---|
| Synonyms |
sulfosuccinimidyl oleate
2,5-Dioxo-1-[[(9Z)-1-oxo-9-octadecenyl]oxy]-3-pyrrolidinesulfonic Acid Sodium Sulfosuccinimidyl Oleate Sodium sulfo-N-succinimidyl oleate (Z)-2,5-Dioxo-1-[(1-oxo-9-octadecenyl)oxy]-3-pyrrolidinesulfonic Acid Sodium |
| Description | Sulfosuccinimidyl oleate is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect[1]. |
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| Related Catalog | |
| In Vitro | Sulfosuccinimidyl oleate (20 μM and 50 μM, 24 hours) alone does not alter the cellular viability. Exposure to 100 ng/ml LPS+5 ng/mL IFNγ modestly, yet significantly reduces the viability of the BV2 cells. Co-treatment with Sulfosuccinimidyl oleate prevents the LPS+IFNγ-induced reduction in the cell viability[1]. Sulfosuccinimidyl oleate (50 μM, 24 hours) co-treatment significantly reduces the LPS+IFNγ-induced expression of NOS2 and COX-2 in BV2 cells. Western blot analysis reveals a significant LPS/IFNγ-induced upregulation in the phosphorylated form of the p38, which is prevented by co-treatment with Sulfosuccinimidyl oleate (50 μM, 24 hours)[1]. Cell Viability Assay[1] Cell Line: BV2 cells Concentration: 20 μM and 50 μM Incubation Time: 24 hours Result: Did not alter the viability of BV2 cells alone. Exposure of BV2 cells to 100 ng/mL LPS and 5 ng/mL IFNγ significantly reduced the viability of BV2 cells while simultaneous treatment with Sulfosuccinimidyl oleate prevented it. Western Blot Analysis[1] Cell Line: BV2 cells Concentration: 50 μM Incubation Time: 24 hours Result: Drastically increased the levels of NOS2, COX-2, and P-p38/T-p38. |
| In Vivo | Sulfosuccinimidyl oleate (50 mg/kg; administered once by single oral gavage) significantly reduces the cortical ischemic infarct size compared to vehicle-treated controls in male BALB/cABom mice with pMCAo model. In addition, Sulfosuccinimidyl oleate at 50 mg/kg is suitable to see a beneficial effect after stroke[1]. Animal Model: 4-month-old male BALB/cABom mice with pMCAo model[1] Dosage: 50 mg/kg Administration: Administered once by single oral gavage Result: Reduced brain damage following ischemia. Attenuated infarct size. |
| References |
| Density | 1.19g/cm3 |
|---|---|
| Melting Point | 220-222ºC |
| Molecular Formula | C22H36NNaO7S |
| Molecular Weight | 481.57900 |
| Exact Mass | 481.21100 |
| PSA | 129.26000 |
| LogP | 5.17350 |
| Index of Refraction | 1.526 |
| Storage condition | -20°C |
| Hazard Codes | Xi |
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