54984-93-9

54984-93-9 structure

Name: Acetylshikonin
Chemical Name: acethylshikonin
CAS Number: 54984-93-9
Molecular Formula: C₁₈H₁₈O₆
Molecular Weight: 330.33200
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
Create Date: 2018-08-10 17:52:31
Modify Date: 2024-01-03 18:11:32
DL-Acetylshikonin is a non-selective, reversible Cytochrome P450 inhibitor with IC50 values of 1.4-4.0 μM. DL-Acetylshikonin has anti-cancer and anti-inflammatory activities[1].

Name	acethylshikonin
Synonyms	shikonin acetate 1'O-acetylshikonin 2-[1-(acetyloxy)-4-methyl-3-pentenyl]naphthazarin acetyl shikonin 1,4-Naphthalenedione,2-(1-(acetyloxy)-4-methyl-3-pentenyl)-5,8-dihydroxy

Description	DL-Acetylshikonin is a non-selective, reversible Cytochrome P450 inhibitor with IC50 values of 1.4-4.0 μM. DL-Acetylshikonin has anti-cancer and anti-inflammatory activities[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Inflammation/Immunology
Target	CYP2C8:1.4 μM (IC50) CYP2B6:2.0 μM (IC50) CYP3A:2.3 μM (IC50) CYP2C19:2.5 μM (IC50) CYP2D6:2.5 μM (IC50) CYP2E1:2.7 μM (IC50) CYP2C9:3.3 μM (IC50) CYP2J2:3.3 μM (IC50) CYP2A6:3.8 μM (IC50) CYP1A2:4.0 μM (IC50)
In Vitro	DL-Acetylshikonin 抑制 CYP3A 介导的睾酮 (testosterone) 和 Nifedipine (HY-B0284) 代谢，IC50 值分别为 5.2 μM 和 3.0 μM，表明其以不依赖底物的方式抑制 CYP3A 活性[1]。 DL-Acetylshikonin 不是一种时间依赖性抑制剂[1]。
References	[1]. Shon JC, et al. Acetylshikonin is a novel non-selective cytochrome P450 inhibitor. Biopharm Drug Dispos. 2017 Dec;38(9):553-556.