70989-04-7

70989-04-7 structure

Name: (S)-Mephenytoin
Chemical Name: (s)-mephenytoin
CAS Number: 70989-04-7
Molecular Formula: C₁₂H₁₄N₂O₂
Molecular Weight: 218.252
Catalog: Research Areas Neurological Disease
Create Date: 2018-05-13 08:00:00
Modify Date: 2024-01-07 23:08:07
(S)-Mephenytoin ((+)-Mephenytoin) is an anticonvulsive agent. (S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19. (S)-Mephenytoin can be used for the analysis of cytochrome P450 metabolism[1][2].

Name	(s)-mephenytoin
Synonyms	S(+)-5-Ethyl-3-methyl-5-phenylhydantoin S(+)-5-Ethyl-1-methyl-5-phenylbarbituric acid S-mephenytoin (+)-Mephobarbitol 5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione 5-éthyl-3-méthyl-5-phénylimidazolidine-2,4-dione 5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione (S)-Mephenytoin mephenytoin (5S)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione [14C]-(+)-Mephenytoin UNII:R420KW629U 5-Ethyl-3-methyl-5-phenylimidazolidin-2,4-dion 2,4,6(1H,3H,5H)-Pyrimidinetrione,5-ethyl-1-methyl-5-phenyl-,(S) (+)-Mephobarbital Gerot-Epilan (5R)-mephobarbital (S)-5-Ethyl-1-methyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione 2,4-Imidazolidinedione, 5-ethyl-3-methyl-5-phenyl- (S)-Methylphenobarbital UNII-5NC67NU76B component ALARQZQTBTVLJV-ZDUSSCGKSA-N 2,4-Imidazolidinedione, 5-ethyl-3-methyl-5-phenyl-, (5S)-

Description	(S)-Mephenytoin ((+)-Mephenytoin) is an anticonvulsive agent. (S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19. (S)-Mephenytoin can be used for the analysis of cytochrome P450 metabolism[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	In the presence of cytochrome b5, the Km for S-mephenytoin is 1.25 mM with all five purified cytochrome P-450s preparations[1].
References	[1]. Shimada T, et, al. Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction. J Biol Chem. 1986 Jan 15;261(2):909-21. [2]. Goldstein JA, et, al. Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans. Biochemistry. 1994 Feb 22;33(7):1743-52.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	22-36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport

Precursor 0
DownStream 1
65567-34-2