Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2,1,3-BENZOXADIAZOLE-4-SULFONAMIDE,7-(3-AMINO-1-PYRROLIDINYL)-N,N-DIMETHYL-,(S)-(9CI)
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Purity: 98.0%
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71140-51-7

71140-51-7 structure

71140-51-7 structure

Name: (R)-Mephenytoin
Chemical Name: (R)-Mephenytoin
CAS Number: 71140-51-7
Molecular Formula: C₁₂H₁₄N₂O₂
Molecular Weight: 218.25200
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
Create Date: 2018-04-04 08:00:00
Modify Date: 2024-01-05 11:29:03
(R)-Mephenytoin ((-)-Mephenytoin), the R-enantiomer of Mephenytoin. Mephenytoin is an Anticonvulsant agent[1][2].

Name	(R)-Mephenytoin
Synonyms	(r)-(-)-mephenytoin

Description	(R)-Mephenytoin ((-)-Mephenytoin), the R-enantiomer of Mephenytoin. Mephenytoin is an Anticonvulsant agent[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Neurological Disease
In Vitro	(R)-Mephenytoin can be N-demethylated by the cytochrome P450 (CYP) isoform CYP2C9 to form the metabolite 5-phenyl-5-ethylhydantoin (nirvanol)[1].
References	[1]. Meier UT, et, al. Assay of mephenytoin metabolism in human liver microsomes by high-performance liquid chromatography. Anal Biochem. 1985 Dec;151(2):286-91. [2]. Relling MV, et, al. Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily. J Pharmacol Exp Ther. 1990 Jan;252(1):442-7.

Density	1.154g/cm3
Melting Point	137-138ºC
Molecular Formula	C₁₂H₁₄N₂O₂
Molecular Weight	218.25200
Exact Mass	218.10600
PSA	49.41000
LogP	1.74020
Index of Refraction	1.541

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	22-36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport