110414-77-2

110414-77-2 structure

Name: Gelsemiol
Chemical Name: (3R,3aS,4R,5S,6aS)-3,4-Bis(hydroxymethyl)-5-methylhexahydro-2H-cy clopenta[b]furan-2-one
CAS Number: 110414-77-2
Molecular Formula: C₁₀H₁₆O₄
Molecular Weight: 200.232
Catalog: Natural product Iridoid derivative
Create Date: 2016-03-01 16:12:51
Modify Date: 2024-01-17 05:57:24
Gelsemiol is the main active ingredient in Verbena littoralis H. B. K.. Gelsemiol enhanced nerve growth factor (NGF) -induced axonal elongation in PC12D cells[1].

Name	(3R,3aS,4R,5S,6aS)-3,4-Bis(hydroxymethyl)-5-methylhexahydro-2H-cy clopenta[b]furan-2-one
Synonyms	2H-Cyclopenta[b]furan-2-one, hexahydro-3,4-bis(hydroxymethyl)-5-methyl-, (3R,3aS,4R,5S,6aS)- (3R,3aS,4R,5S,6aS)-3,4-Bis(hydroxymethyl)-5-methylhexahydro-2H-cyclopenta[b]furan-2-one

Description	Gelsemiol is the main active ingredient in Verbena littoralis H. B. K.. Gelsemiol enhanced nerve growth factor (NGF) -induced axonal elongation in PC12D cells[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Gelsemiol (30-300μM; 48 h) 在 PC12D 细胞中，不单独显示神经炎诱导活性[1]。 Gelsemiol (30-300μM; 48 h) 在 PC12D 细胞中，和 NGF (2 ng/mL) 一起显著增强了携带轴突的细胞比例的增加和轴突长度的延长[1]。
References	[1]. Li YS, et al. Potentiation of nerve growth factor-induced elongation of neurites by gelsemiol and 9-hydroxysemperoside aglucone in PC12D cells. J Pharm Pharmacol. 2001 Jun;53(6):915-9.

Hazard Codes	Xi