Gelsemiol

Modify Date: 2024-01-17 05:57:24

Gelsemiol Structure
Gelsemiol structure
Common Name Gelsemiol
CAS Number 110414-77-2 Molecular Weight 200.232
Density 1.2±0.1 g/cm3 Boiling Point 407.0±10.0 °C at 760 mmHg
Molecular Formula C10H16O4 Melting Point N/A
MSDS N/A Flash Point 164.2±12.5 °C

 Use of Gelsemiol


Gelsemiol is the main active ingredient in Verbena littoralis H. B. K.. Gelsemiol enhanced nerve growth factor (NGF) -induced axonal elongation in PC12D cells[1].

 Names

Name (3R,3aS,4R,5S,6aS)-3,4-Bis(hydroxymethyl)-5-methylhexahydro-2H-cy clopenta[b]furan-2-one
Synonym More Synonyms

 Gelsemiol Biological Activity

Description Gelsemiol is the main active ingredient in Verbena littoralis H. B. K.. Gelsemiol enhanced nerve growth factor (NGF) -induced axonal elongation in PC12D cells[1].
Related Catalog
In Vitro Gelsemiol (30-300μM; 48 h) 在 PC12D 细胞中,不单独显示神经炎诱导活性[1]。 Gelsemiol (30-300μM; 48 h) 在 PC12D 细胞中,和 NGF (2 ng/mL) 一起显著增强了携带轴突的细胞比例的增加和轴突长度的延长[1]。
References

[1]. Li YS, et al. Potentiation of nerve growth factor-induced elongation of neurites by gelsemiol and 9-hydroxysemperoside aglucone in PC12D cells. J Pharm Pharmacol. 2001 Jun;53(6):915-9.  

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 407.0±10.0 °C at 760 mmHg
Molecular Formula C10H16O4
Molecular Weight 200.232
Flash Point 164.2±12.5 °C
Exact Mass 200.104858
PSA 66.76000
LogP -1.33
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.499

 Safety Information

Hazard Codes Xi

 Synonyms

2H-Cyclopenta[b]furan-2-one, hexahydro-3,4-bis(hydroxymethyl)-5-methyl-, (3R,3aS,4R,5S,6aS)-
(3R,3aS,4R,5S,6aS)-3,4-Bis(hydroxymethyl)-5-methylhexahydro-2H-cyclopenta[b]furan-2-one
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