Shanghai Nianxing Industrial Co., Ltd
China
Product Name: GRI 977143
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Purity: 98.0%
Stocking Period: 10 Day
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DC Chemicals Limited
China
Product Name: GRI 977143
Price: $700.0/100mg $1150.0/250mg $2200.0/500mg $220.0/10ml
Purity: 98.0%
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: GRI 977143
Price: ￥Inquiry/1g
Purity: 98.9%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propylsulfanyl]-benzoic acid
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Purity: 98.0%
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325850-81-5

325850-81-5 structure

325850-81-5 structure

Name: GRI 977143
Chemical Name: 2-[3-(1,3-dioxobenzo[de]isoquinolin-2-yl)propylsulfanyl]benzoic acid
CAS Number: 325850-81-5
Molecular Formula: C₂₂H₁₇NO₄S
Molecular Weight: 391.44000
Catalog: Signaling Pathways Apoptosis Caspase
Create Date: 2019-01-01 17:14:42
Modify Date: 2024-01-10 19:19:51
GRI977143 is a specific LPA2 receptor agonist, with an EC50 of 3.3 μM [1].

Name	2-[3-(1,3-dioxobenzo[de]isoquinolin-2-yl)propylsulfanyl]benzoic acid
Synonyms	f0223-0003 unii-m3l07r4zep GRI 977143

Description	GRI977143 is a specific LPA2 receptor agonist, with an EC50 of 3.3 μM [1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> LPL Receptor Signaling Pathways >> Apoptosis >> Caspase Research Areas >> Inflammation/Immunology
Target	LPA2 Receptor:3.3 μM (EC50)
In Vitro	GRI977143 (10 μM, 24-72 h) is effective in reducing activation of caspases 3, 7, 8, and 9 and inhibits poly(ADP-ribose)polymerase 1 cleavage and DNA fragmentation in different extrinsic and intrinsic models of apoptosis[1]. GRI977143 is an effective stimulator of extracellular signal-regulated kinase 1/2 activation and promotes the assembly of a macromolecular signaling complex consisting of LPA2, Na+-H+ exchange regulatory factor 2, and thyroid receptor interacting protein 6[1]. Cell Proliferation Assay[1] Cell Line: Vector- and LPA2-transduced MEF cells (2 × 104)[1]. Concentration: 10 μM. Incubation Time: 24-72 h. Result: Did not cause a significant increase in vector cell proliferation except at 72 h (p < 0.05). Apoptosis Analysis[1]. Cell Line: Doxorubicin-induced apoptotic signaling in vector-transduced or LPA2-transduced MEF. Concentration: 10 μM. Incubation Time: 24 h. Result: Reduced caspase 3 and 7 activation on LPA2-transduced MEF cells by 51 ± 3% and was approximately as potent as 3 μM LPA or OTP. Protected against doxorubicin-induced apoptosis by inhibiting caspase 3, 7, 8, and 9 and reducing DNA fragmentation.
References	[1]. Gyöngyi N. Kiss, et al. Virtual Screening for LPA2-Specific Agonists Identifies a Nonlipid Compound with Antiapoptotic Actions. Mol Pharmacol. 2012 Dec; 82(6): 1162–1173. [2]. Gyöngyi Nagyné Kiss, et al. PHARMACOLOGICAL AND CELLULAR CHARACTERIZATION OF GRI977143, A NOVEL NONLIPID LPA2 RECEPTOR AGONIST IDENTIFIED BY VIRTUAL SCREENING.

Molecular Formula	C₂₂H₁₇NO₄S
Molecular Weight	391.44000
Exact Mass	391.08800
PSA	101.67000
LogP	3.83330

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H302-H410
Precautionary Statements	P273-P501
RIDADR	UN 3077 9 / PGIII
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%