4214-72-6

4214-72-6 structure

Name: Isaxonine
Chemical Name: N-propan-2-ylpyrimidin-2-amine
CAS Number: 4214-72-6
Molecular Formula: C₇H₁₁N₃
Molecular Weight: 137.18200
Create Date: 2018-06-24 13:13:08
Modify Date: 2024-01-11 19:03:05
Isaxonine acts as a modifier of the surface pH of the bilayer[1]. Isaxonine accelerates the rate of peripheral nerve regeneration, stimulate axonal sprouting and promote motor and sensory function recovery[2]. Isaxonine is a neurotrophic agent[3].

Name	N-propan-2-ylpyrimidin-2-amine
Synonyms	isopropylaminopyrimidine 2-Pyrimidinamine,N-(1-methylethyl) Isaxonine Isaxonina 2-(N-isopropylamino)pyrimidine Isaxonina [INN-Spanish] Isaxoninum Isaxoninum [INN-Latin] isopropyl(pyrimidin-2-yl)amine 2-(ISOPROPYLAMINO)PYRIMIDINE

Description	Isaxonine acts as a modifier of the surface pH of the bilayer[1]. Isaxonine accelerates the rate of peripheral nerve regeneration, stimulate axonal sprouting and promote motor and sensory function recovery[2]. Isaxonine is a neurotrophic agent[3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Isaxonine has a favourable effect on nerve regeneration. After 8 weeks small type grouping is seen in rats receiving solvent only and large type grouping in rats treated with intraperitoneal Isaxonine. After 10 weeks a checkerboard pattern of the fibre types is observed in the muscles of animals receiving solvent only but fibre type grouping was present in those treated with Isaxonine. Isaxonine prevents synaptic remodelling by suppression of the redundant nerve endings from additional axons, which have regenerated more slowly, in making contact with motor endplates[4]. Isaxonine phosphate induces acute hepatitis which in most cases is reversible after withdrawal of the compound[5].
References	[1]. De Bleecker J, et al. Influence of isaxonine on the target phenomenon, muscle fibre size and neuromuscular junction in the tenotomized and denervated gastrocnemius muscle of the rat. Acta Neuropathol. 1986;69(3-4):337-340. [2]. J De Bleecker, et al. Influence of Isaxonine on the target phenomenon, muscle fibre size and neuromuscular junction in the tenotomized and denervated gastrocnemius muscle of the rat. Acta Neuropathol. 1986;69(3-4):337-40. [3]. C M Becker, et al. Nerve and muscle regeneration after axonal division in rats treated with Isaxonine phosphate (isopropylamino-2-pyrimidine phosphate). Eur Surg Res. 1986;18(6):383-9. [4]. J De Reuck, et al. Influence of Isaxonine on reinnervation of the rat gastrocnemius muscle. Acta Neuropathol. 1987;72(4):406-8. [5]. A Davy, et al. [Hepatotoxicity of Isaxonine phosphate: 4 cases of severe subacute hepatitis]. Gastroenterol Clin Biol. 1984 Oct;8(10):715-9.

Density	1.065 g/cm3
Boiling Point	229.3ºC at 760mmHg
Melting Point	27-28ºC
Molecular Formula	C₇H₁₁N₃
Molecular Weight	137.18200
Flash Point	92.5ºC
Exact Mass	137.09500
PSA	37.81000
LogP	1.36990
Index of Refraction	1.554

HS Code	2933599090

1722-12-9

75-31-0

~81%

4214-72-6

Literature: Ermolat'ev, Denis S.; Van Der Eycken, Erik V. Journal of Organic Chemistry, 2008 , vol. 73, # 17 p. 6691 - 6697

1722-12-9

2016-57-1

~88%

4214-72-6

Literature: Steenackers, Hans P. L.; Ermolatev, Denis S.; Savaliya, Bharat; De Weerdt, Ami; De Coster, David; Shah, Anamik; Van Der Eycken, Erik V.; De Vos, Dirk E.; Vanderleyden, Jozef; De Keersmaecker, Sigrid C. J. Journal of Medicinal Chemistry, 2011 , vol. 54, # 2 p. 472 - 484

Precursor 3
1722-12-9 75-31-0 2016-57-1
DownStream 0

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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