Shanghai Nianxing Industrial Co., Ltd
China
Product Name: KR-32568
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: KR-32568
Price: ￥880.0/100mg
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao

852146-73-7

852146-73-7 structure

852146-73-7 structure

Name: KR-32568
Chemical Name: N-(diaminomethylidene)-5-(5-fluoro-2-methylphenyl)furan-2-carboxamide
CAS Number: 852146-73-7
Molecular Formula: C₁₃H₁₂FN₃O₂
Molecular Weight: 261.25200
Catalog: Research Areas Cardiovascular Disease
Create Date: 2017-03-08 20:50:23
Modify Date: 2024-02-05 14:09:20
KR-32568 is a sodium/hydrogen exchanger-1 (NHE-1) inhibitor with an IC50 of 230 nM. KR-32568 has cardioprotective effects[1][2].

Name	N-(diaminomethylidene)-5-(5-fluoro-2-methylphenyl)furan-2-carboxamide
Synonyms	[5-(2-Methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine

Description	KR-32568 is a sodium/hydrogen exchanger-1 (NHE-1) inhibitor with an IC50 of 230 nM. KR-32568 has cardioprotective effects[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease
Target	IC50: 230 nM (NHE-1)[2]
In Vitro	KR-32568 (10 nM-1 μM) 以浓度依赖性方式抑制 NHE-1 介导的兔富血小板血浆细胞内酸化引起的血小板肿胀，IC50 值为 24 nM[1]。
In Vivo	KR-32568（0.1-1.0 mg/kg；i.v.；一次）对大鼠发挥有效的心脏保护作用，例如减少梗塞面积，并显着减少室性早搏的总数[1]。 Animal Model: Male Sprague-Dawley rats (350-380 g) bearing 30 min ischemia/2.5 h reperfusion heart injury[1] Dosage: 0.1 mg/kg and 1.0 mg/kg Administration: i.v.; once Result: Exerted potent cardioprotective effects in rats.
References	[1]. Hui-Yul Roh, et al. Cardioprotective effects of [5-(2-methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine (KR-32568) in an anesthetized rat model of ischemia and reperfusion heart injury. Pharmacology. 2005 Dec;75(1):37-44. [2]. Sunkyung Lee, et al. (5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1. J Med Chem. 2005 Apr 21;48(8):2882-91.

Density	1.38g/cm3
Boiling Point	444.1ºC at 760 mmHg
Molecular Formula	C₁₃H₁₂FN₃O₂
Molecular Weight	261.25200
Flash Point	222.4ºC
Exact Mass	261.09100
PSA	92.11000
LogP	3.20830
Index of Refraction	1.617

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
RIDADR	NONH for all modes of transport