KR-32568
Modify Date: 2024-02-05 14:09:20
KR-32568 structure
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Common Name | KR-32568 | ||
|---|---|---|---|---|
| CAS Number | 852146-73-7 | Molecular Weight | 261.25200 | |
| Density | 1.38g/cm3 | Boiling Point | 444.1ºC at 760 mmHg | |
| Molecular Formula | C13H12FN3O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 222.4ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of KR-32568KR-32568 is a sodium/hydrogen exchanger-1 (NHE-1) inhibitor with an IC50 of 230 nM. KR-32568 has cardioprotective effects[1][2]. |
| Name | N-(diaminomethylidene)-5-(5-fluoro-2-methylphenyl)furan-2-carboxamide |
|---|---|
| Synonym | More Synonyms |
| Description | KR-32568 is a sodium/hydrogen exchanger-1 (NHE-1) inhibitor with an IC50 of 230 nM. KR-32568 has cardioprotective effects[1][2]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 230 nM (NHE-1)[2] |
| In Vitro | KR-32568 (10 nM-1 μM) 以浓度依赖性方式抑制 NHE-1 介导的兔富血小板血浆细胞内酸化引起的血小板肿胀，IC50 值为 24 nM[1]。 |
| In Vivo | KR-32568（0.1-1.0 mg/kg；i.v.；一次）对大鼠发挥有效的心脏保护作用，例如减少梗塞面积，并显着减少室性早搏的总数[1]。 Animal Model: Male Sprague-Dawley rats (350-380 g) bearing 30 min ischemia/2.5 h reperfusion heart injury[1] Dosage: 0.1 mg/kg and 1.0 mg/kg Administration: i.v.; once Result: Exerted potent cardioprotective effects in rats. |
| References |
| Density | 1.38g/cm3 |
|---|---|
| Boiling Point | 444.1ºC at 760 mmHg |
| Molecular Formula | C13H12FN3O2 |
| Molecular Weight | 261.25200 |
| Flash Point | 222.4ºC |
| Exact Mass | 261.09100 |
| PSA | 92.11000 |
| LogP | 3.20830 |
| Index of Refraction | 1.617 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| RIDADR | NONH for all modes of transport |
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Carbonic anhydrase activation is associated with worsened pathological remodeling in human ischemic diabetic cardiomyopathy.
J. Am. Heart Assoc. 3(2) , e000434, (2014) Diabetes mellitus (DM) has multifactorial detrimental effects on myocardial tissue. Recently, carbonic anhydrases (CAs) have been shown to play a major role in diabetic microangiopathy but their role ... |
| [5-(2-Methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine |