525596-66-1

525596-66-1 structure

Name: bPiDDB
Chemical Name: 1,1'-(1,12-Dodecanediyl)bis(3-methylpyridinium) dibromide
CAS Number: 525596-66-1
Molecular Formula: C₂₄H₃₈Br₂N₂
Molecular Weight: 514.38000
Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
Create Date: 2017-07-02 11:35:03
Modify Date: 2024-02-17 09:23:03
bPiDDB is a potent nAChR antagonist. bPiDDB potently (IC50=2 nM) inhibits nicotine-evoked striatal dopamine (DA) release through an interaction with α6β2-containing nAChRs[1].

Name	1,1'-(1,12-Dodecanediyl)bis(3-methylpyridinium) dibromide

Description	bPiDDB is a potent nAChR antagonist. bPiDDB potently (IC50=2 nM) inhibits nicotine-evoked striatal dopamine (DA) release through an interaction with α6β2-containing nAChRs[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
In Vivo	bPiDDB (外周给药) 可抑制伏隔核中尼古丁诱发的多巴胺 (DA) 释放，降低大鼠尼古丁的成瘾性[1]。 bPiDDB 在外周给药后具有脑生物可利用性，并由血脑屏障胆碱转运体主动运输到中央室[1]。
References	[1]. Smith AM, et al. Repeated nicotine administration robustly increases bPiDDB inhibitory potency at alpha6beta2-containing nicotinic receptors mediating nicotine-evoked dopamine release. Biochem Pharmacol. 2010 Aug 1;80(3):402-9.